دورية أكاديمية
Assessing cardiovascular risk in ATM heterozygotes.
| العنوان: | Assessing cardiovascular risk in ATM heterozygotes. |
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| المؤلفون: | Kotchetkoff ECA; Pediatrics Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Souza FIS; Pediatrics Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Fonseca FLA; Faculdade de Medicina do ABC, Santo André, SP, Brazil., Hix S; Department of Morphology and Physiology, Faculdade de Medicina do ABC, Santo André, SP, Brazil., Ajzen SA; Department of Diagnostic Imaging, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Shigueoka DC; Department of Diagnostic Imaging, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Carvalho BTC; Pediatrics Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil., Sarni ROS; Pediatrics Department, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brazil. |
| المصدر: | Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2018 Feb; Vol. 64 (2), pp. 148-153. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Associação Médica Brasileira Country of Publication: Brazil NLM ID: 9308586 Publication Model: Print Cited Medium: Internet ISSN: 1806-9282 (Electronic) Linking ISSN: 01044230 NLM ISO Abbreviation: Rev Assoc Med Bras (1992) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: São Paulo : Associação Médica Brasileira |
| مواضيع طبية MeSH: | Carotid Intima-Media Thickness* , Heterozygote*, Ataxia Telangiectasia/*blood , Cardiovascular Diseases/*diagnosis, Adult ; Ataxia Telangiectasia/genetics ; Biomarkers/blood ; C-Reactive Protein/analysis ; Carotid Arteries ; Case-Control Studies ; Cholesterol, HDL/blood ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Nutritional Status ; Parents ; Risk Assessment ; Risk Factors ; Sex Factors |
| مستخلص: | Objective: To evaluate the carotid intima-media complex (CIMC) thickness and lipid metabolism biomarkers associated with cardiovascular risk (CR) in parents of patients with ataxia-telangiectasia and verify an association with gender. Method: A cross-sectional and controlled study with 29 ATM heterozygotes and 14 healthy controls. Biochemical tests and CIMC thickness measurement were performed. Results: The mean CIMC measurement in heterozygous ATM was 0.72 ± 0.1 mm (minimum: 0.5 mm and maximum: 1.0 mm). Noticed high percentage of amounts above 75 percentile compared to the population referential (16 [76.2%]), without any significant statistical differences between the female and the male gender (11/15 [73.3%] vs. 5/6 [83.3%]; p=0.550). The comparison between heterozygous and controls, stratified by gender, showed that in heterozygous ATMs, women had higher concentrations of HDL-c compared to men, as well as higher values of hs-CRP in relation to the control women. In heterozygous ATMs, stratified by gender, the correlation between HDL-c and hs-CRP was inversely proportional and stronger among women, with a tendency to statistical significance. Conclusion: Heterozygous ATMs did not differ from controls in relation to the biomarkers studied related to CR. However, most of them presented increased CIMC, independent predictor of death, risk for myocardial infarction and stroke, compared to the referential for the same age group. This finding suggests CR in the heterozygous ATM and shows to the need to monitor CIMC thickness and nutritional orientations. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cholesterol, HDL) 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20180412 Date Completed: 20180427 Latest Revision: 20180427 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1590/1806-9282.64.02.148 |
| PMID: | 29641672 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1806-9282 |
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| DOI: | 10.1590/1806-9282.64.02.148 |