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S6 kinase 1 plays a key role in mitochondrial morphology and cellular energy flow.

التفاصيل البيبلوغرافية
العنوان: S6 kinase 1 plays a key role in mitochondrial morphology and cellular energy flow.
المؤلفون: Tran Q; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Jung JH; Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin 17104, South Korea., Park J; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Lee H; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Hong Y; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Cho H; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Kim M; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Park S; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Kwon SH; College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon 21983, South Korea., Kim SH; Department of Neurosurgery, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea., Thomas G; Laboratory of Metabolism and Cancer, Catalan Institute of Oncology, ICO, Bellvitge Biomedical Research Institute, IDIBELL, 08908 Barcelona, Spain., Kim KP; Department of Applied Chemistry, Institute of Natural Science, Global Center for Pharmaceutical Ingredient Materials, Kyung Hee University, Yongin 17104, South Korea; Department of Biomedical Science and Technology, Kyung Hee Medical Science Research Institute, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: kimkp@khu.ac.kr., Cho MH; Laboratory of Toxicology, College of Veterinary Medicine Seoul National University, Seoul 08826, South Korea. Electronic address: mchotox@snu.ac.kr., Park J; Department of Pharmacology and Medical Science, Metabolic Syndrome and Cell Signaling Laboratory, Institute for Cancer Research, College of Medicine, Chungnam National University, Daejeon 35015, South Korea. Electronic address: insulin@cnu.ac.kr.
المصدر: Cellular signalling [Cell Signal] 2018 Aug; Vol. 48, pp. 13-24. Date of Electronic Publication: 2018 Apr 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 8904683 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3913 (Electronic) Linking ISSN: 08986568 NLM ISO Abbreviation: Cell Signal Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Elsevier Science Ltd
Original Publication: Oxford ; New York : Pergamon Press, 1988-
مواضيع طبية MeSH: Energy Metabolism/*physiology , Mitochondria/*metabolism , Mitochondrial Dynamics/*physiology , Mitophagy/*physiology , Ribosomal Protein S6 Kinases, 90-kDa/*physiology, Animals ; Autophagy ; Dynamins/antagonists & inhibitors ; Dynamins/metabolism ; Embryo, Mammalian ; Fibroblasts ; Gene Knockout Techniques ; Glycolysis ; Homeostasis ; Membrane Potential, Mitochondrial ; Mice ; Ribosomal Protein S6 Kinases, 90-kDa/genetics
مستخلص: Mitochondrial morphology, which is associated with changes in metabolism, cell cycle, cell development and cell death, is tightly regulated by the balance between fusion and fission. In this study, we found that S6 kinase 1 (S6K1) contributes to mitochondrial dynamics, homeostasis and function. Mouse embryo fibroblasts lacking S6K1 (S6K1-KO MEFs) exhibited more fragmented mitochondria and a higher level of Dynamin related protein 1 (Drp1) and active Drp1 (pS616) in both whole cell extracts and mitochondrial fraction. In addition, there was no evidence for autophagy and mitophagy induction in S6K1 depleted cells. Glycolysis and mitochondrial respiratory activity was higher in S6K1-KO MEFs, whereas OxPhos ATP production was not altered. However, inhibition of Drp1 by Mdivi1 (Drp1 inhibitor) resulted in higher OxPhos ATP production and lower mitochondrial membrane potential. Taken together the depletion of S6K1 increased Drp1-mediated fission, leading to the enhancement of glycolysis. The fission form of mitochondria resulted in lower yield for OxPhos ATP production as well as in higher mitochondrial membrane potential. Thus, these results have suggested a potential role of S6K1 in energy metabolism by modulating mitochondrial respiratory capacity and mitochondrial morphology.
(Copyright © 2018. Published by Elsevier Inc.)
فهرسة مساهمة: Keywords: Drp1*; Fission*; Metabolic shift*; Mitophagy*; OxPhos*; S6K1*
المشرفين على المادة: EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 90-kDa)
EC 2.7.11.1 (Rps6ka1 protein, mouse)
EC 3.6.5.5 (Dnm1l protein, mouse)
EC 3.6.5.5 (Dynamins)
تواريخ الأحداث: Date Created: 20180421 Date Completed: 20190917 Latest Revision: 20191210
رمز التحديث: 20231215
DOI: 10.1016/j.cellsig.2018.04.002
PMID: 29673648
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3913
DOI:10.1016/j.cellsig.2018.04.002