دورية أكاديمية
أعرض في EDS

Biological recognition of graphene nanoflakes.

التفاصيل البيبلوغرافية
العنوان: Biological recognition of graphene nanoflakes.
المؤلفون: Castagnola V; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland. valentina.castagnola@cbni.ucd.ie., Zhao W; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland., Boselli L; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland., Lo Giudice MC; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland., Meder F; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland., Polo E; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland., Paton KR; School of Physics, CRANN and AMBER, Trinity College Dublin, Dublin, 2, Ireland., Backes C; School of Physics, CRANN and AMBER, Trinity College Dublin, Dublin, 2, Ireland., Coleman JN; School of Physics, CRANN and AMBER, Trinity College Dublin, Dublin, 2, Ireland., Dawson KA; Centre for BioNano Interactions, School of Chemistry, University College Dublin, Belfield, Dublin, 4, Ireland. kenneth.a.dawson@cbni.ucd.ie.
المصدر: Nature communications [Nat Commun] 2018 Apr 20; Vol. 9 (1), pp. 1577. Date of Electronic Publication: 2018 Apr 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مستخلص: The systematic study of nanoparticle-biological interactions requires particles to be reproducibly dispersed in relevant fluids along with further development in the identification of biologically relevant structural details at the materials-biology interface. Here, we develop a biocompatible long-term colloidally stable water dispersion of few-layered graphene nanoflakes in the biological exposure medium in which it will be studied. We also report the study of the orientation and functionality of key proteins of interest in the biolayer (corona) that are believed to mediate most of the early biological interactions. The evidence accumulated shows that graphene nanoflakes are rich in effective apolipoprotein A-I presentation, and we are able to map specific functional epitopes located in the C-terminal portion that are known to mediate the binding of high-density lipoprotein to binding sites in receptors that are abundant in the liver. This could suggest a way of connecting the materials' properties to the biological outcomes.
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تواريخ الأحداث: Date Created: 20180422 Date Completed: 20181120 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC5910434
DOI: 10.1038/s41467-018-04009-x
PMID: 29679022
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-018-04009-x