دورية أكاديمية
Silicosis decreases bone mineral density in rats.
| العنوان: | Silicosis decreases bone mineral density in rats. |
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| المؤلفون: | Hui Z; Medical Research Center, North China University of Science and Technology, Tangshan, China., Dingjie X; College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, China., Yuan Y; Pathology Department, Beijing Tiantan Hospital, Beijing, China., Zhongqiu W; Medical Research Center, North China University of Science and Technology, Tangshan, China., Na M; Medical Research Center, North China University of Science and Technology, Tangshan, China., Mingjian B; Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, United States., Yu G; Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, United States., Guangyuan L; Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, United States., Xuemin G; Medical Research Center, North China University of Science and Technology, Tangshan, China., Shifeng L; Medical Research Center, North China University of Science and Technology, Tangshan, China., Yucong G; Medical Research Center, North China University of Science and Technology, Tangshan, China., Fang Y; Medical Research Center, North China University of Science and Technology, Tangshan, China., Summer R; Center for Translational Medicine, Jane and Leonard Korman Respiratory Institute, Thomas Jefferson University, Philadelphia, PA, United States. Electronic address: ross.summer@jefferson.edu., Hong X; Medical Research Center, North China University of Science and Technology, Tangshan, China. Electronic address: Hong.Xu2@jefferson.edu. |
| المصدر: | Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2018 Jun 01; Vol. 348, pp. 117-122. Date of Electronic Publication: 2018 Apr 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Academic Press Original Publication: New York. |
| مواضيع طبية MeSH: | Bone Density* , Silicon Dioxide*, Femur/*pathology , Lung/*pathology , Osteoporosis/*chemically induced , Pulmonary Fibrosis/*chemically induced , Silicosis/*etiology , Tibia/*pathology, Animals ; Calcium/blood ; Collagen/metabolism ; Disease Models, Animal ; Femur/diagnostic imaging ; Lung/metabolism ; Male ; Osteoclasts/drug effects ; Osteoclasts/metabolism ; Osteoclasts/pathology ; Osteoporosis/blood ; Osteoporosis/diagnostic imaging ; Osteoporosis/pathology ; Pulmonary Fibrosis/metabolism ; Pulmonary Fibrosis/pathology ; Rats, Wistar ; Risk Assessment ; Severity of Illness Index ; Silicosis/metabolism ; Silicosis/pathology ; Tibia/diagnostic imaging ; Time Factors ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; X-Ray Microtomography |
| مستخلص: | Silicosis is the most common occupational lung disease in China, and is associated with a variety of complications, many of which are poorly understood. For example, recent data indicate that silicosis associates with the development of osteopenia, and in some cases this bone loss is severe, meeting criteria for osteoporosis. Although many factors are likely to contribute to this relationship, including a sedentary lifestyle in patients with advanced silicotic lung disease, we hypothesized that silica might directly reduce bone mineral density. In the present study, six Wistar rats were exposed to silica for 24 weeks in order to induce pulmonary silicosis and examine the relationship to bone mineral density. As expected, all rats exposed to silica developed severe pulmonary fibrosis, as manifested by the formation of innumerable silicotic nodules and the deposition of large amounts of interstitial collagen. Moreover, micro-CT results showed that bone mineral density (BMD) was also significantly reduced in rats exposed to silica when compared control animals and this associated with a modest reduction in serum calcium and 25-hydroxyvitamin D levels. In addition, we found that decreased BMD was also linked to increased osteoclast activity as well as fibrosis-like changes, and to the deposition of silica within bone marrow. In summary, our findings support the hypothesis that silicosis reduces bone mineral density and provide support for ongoing investigations into the mechanisms causing osteopenia in silicosis patients. (Copyright © 2018. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: Bone mineral density; Osteoclast; Osteoporosis; Silicosis |
| المشرفين على المادة: | 1406-16-2 (Vitamin D) 7631-86-9 (Silicon Dioxide) 9007-34-5 (Collagen) A288AR3C9H (25-hydroxyvitamin D) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20180423 Date Completed: 20181126 Latest Revision: 20181126 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.taap.2018.04.023 |
| PMID: | 29680408 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1096-0333 |
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| DOI: | 10.1016/j.taap.2018.04.023 |