دورية أكاديمية
أعرض في EDS

Antimicrobial usage and presence of extended-spectrum β-lactamase-producing Enterobacteriaceae in animal-rearing households of selected rural and peri-urban communities.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial usage and presence of extended-spectrum β-lactamase-producing Enterobacteriaceae in animal-rearing households of selected rural and peri-urban communities.
المؤلفون: Okpara EO; Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Abeokuta, Nigeria., Ojo OE; Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Abeokuta, Nigeria; Institute of Microbiology and Epizootics, Center for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Germany. Electronic address: ojooe@funaab.edu.ng., Awoyomi OJ; Department of Veterinary Public Health and Reproduction, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Abeokuta, Nigeria., Dipeolu MA; Department of Veterinary Public Health and Reproduction, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Abeokuta, Nigeria., Oyekunle MA; Department of Veterinary Microbiology and Parasitology, College of Veterinary Medicine, Federal University of Agriculture, Abeokuta, Abeokuta, Nigeria., Schwarz S; Institute of Microbiology and Epizootics, Center for Infection Medicine, Department of Veterinary Medicine, Freie Universität Berlin, Germany.
المصدر: Veterinary microbiology [Vet Microbiol] 2018 May; Vol. 218, pp. 31-39. Date of Electronic Publication: 2018 Mar 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Scientific Pub. Co Country of Publication: Netherlands NLM ID: 7705469 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2542 (Electronic) Linking ISSN: 03781135 NLM ISO Abbreviation: Vet Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam, Elsevier Scientific Pub. Co.
مواضيع طبية MeSH: Drug Utilization* , Family Characteristics*, Anti-Infective Agents/*adverse effects , Enterobacteriaceae/*drug effects , Enterobacteriaceae Infections/*epidemiology , beta-Lactamases/*drug effects, Animals ; Anti-Infective Agents/administration & dosage ; Chickens/microbiology ; Dogs/microbiology ; Enterobacteriaceae/genetics ; Enterobacteriaceae Infections/microbiology ; Enterobacteriaceae Infections/transmission ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Escherichia coli Infections/microbiology ; Humans ; Klebsiella Infections ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Klebsiella pneumoniae/isolation & purification ; Nigeria/epidemiology ; Pets/microbiology ; Phylogeny ; Rural Population/statistics & numerical data ; Sheep/microbiology ; Urban Population/statistics & numerical data ; beta-Lactamases/biosynthesis
مستخلص: This study examined socioeconomic and cultural factors relating to animal husbandry, antimicrobial usage and household hygiene in 320 animal-keeping households of 16 rural and peri-urban communities of Ogun State, Nigeria. The occurrence of extended-spectrum β-lactamase-producing Enterobacteriaceae in 457 samples from animal and environmental sources within the households was investigated. Chickens (41.6%), goats (35.3%), dogs (33.8%) and sheep (14.4%) were the most common household animals. Animals were reared mainly for income generation (73.9%) and for household consumption (18.3%). They were reared predominantly (60.2%-100%) under the extensive system with unrestricted access to human space, cooking utensils and foods. Households were assessed as having good (59.4%), fair (22.2%) and poor (18.4%) hygiene. The rate of household non-prescriptional antimicrobial usage was 69.4% in humans and 60.6% in animals. Overall, ESBL-producing Enterobacteriaceae were detected in 53 (11.6%) of 457 samples. The ESBL-producing isolates were identified as Escherichia coli (n = 49) and Klebsiella pneumoniae (n = 4). They harboured the ESBL gene variants bla CTX-M-15 (n = 49), bla CTX-M-14 (n = 2), bla CTX-M-27 (n = 1) or bla CTX-M-55 (n = 1). Forty-eight ESBL-producing E. coli were assigned into phylogenetic groups A (n = 17), B1 (n = 14), D (n = 13) and F (n = 4). All ESBL-producing isolates demonstrated multidrug resistance to antimicrobial agents belonging to at least three different classes of antimicrobials. Poor regulation of antimicrobial marketing and inadequate access to veterinary care contributed to non-prescriptional use of antimicrobials in humans and animals. Free-range household animals harboured ESBL-producing bacteria and may facilitate the dispersal of the organisms within the community.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Antimicrobial usage; ESBL; Escherichia coli; Household hygiene; Multidrug resistance; Phylogroups; blaCTX-M
المشرفين على المادة: 0 (Anti-Infective Agents)
EC 3.5.2.6 (beta-Lactamases)
تواريخ الأحداث: Date Created: 20180425 Date Completed: 20181120 Latest Revision: 20201209
رمز التحديث: 20240628
DOI: 10.1016/j.vetmic.2018.03.013
PMID: 29685218
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2542
DOI:10.1016/j.vetmic.2018.03.013