دورية أكاديمية
Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia.
| العنوان: | Therapeutic effect of Northern Labrador tea extracts for acute myeloid leukemia. |
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| المؤلفون: | McGill CM; Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, 99508, USA., Tomco PL; Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, 99508, USA., Ondrasik RM; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA, 17033, USA., Belknap KC; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA., Dwyer GK; Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, 99508, USA., Quinlan DJ; Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, 99508, USA., Kircher TA; Department of Chemistry, University of Alaska Anchorage, Anchorage, AK, 99508, USA., Andam CP; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA., Brown TJ; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA, 17033, USA., Claxton DF; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA, 17033, USA., Barth BM; Department of Medicine, Division of Hematology and Oncology, Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA, 17033, USA.; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA. |
| المصدر: | Phytotherapy research : PTR [Phytother Res] 2018 Aug; Vol. 32 (8), pp. 1636-1641. Date of Electronic Publication: 2018 Apr 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London : Heyden & Son, c1987- |
| مواضيع طبية MeSH: | Ledum/*chemistry , Leukemia, Myeloid, Acute/*drug therapy , Plant Extracts/*pharmacology , Triterpenes/*pharmacology, Animals ; Cell Line, Tumor ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Plants, Medicinal/chemistry ; Ursolic Acid |
| مستخلص: | Acute myeloid leukemia (AML) is an aggressive hematological malignancy that is one of the more common pediatric malignancies in addition to occurring with high incidence in the aging population. Unfortunately, these patient groups are quite sensitive to toxicity from chemotherapy. Northern Labrador tea, or Rhododendron tomentosum Harmaja (a.k.a. Ledum palustre subsp. decumbens) or "tundra tea," is a noteworthy medicinal plant used by indigenous peoples in Alaska, Canada, and Greenland to treat a diversity of ailments. However, laboratory investigations of Northern Labrador tea, and other Labrador tea family members, as botanical sources for anticancer compounds have been limited. Utilizing an AML cell line in both in vitro and in vivo studies, as well as in vitro studies using primary human AML patient samples, this study demonstrated for the first time that Northern Labrador tea extracts can exert anti-AML activity and that this may be attributed to ursolic acid as a constituent component. Therefore, this medicinal herb holds the potential to serve as a source for further drug discovery efforts to isolate novel anti-AML compounds. (Copyright © 2018 John Wiley & Sons, Ltd.) |
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| معلومات مُعتمدة: | K22 CA190674 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: Northern Labrador tea; Rhododendron tomentosum; acute myeloid leukemia; ursolic acid |
| المشرفين على المادة: | 0 (Plant Extracts) 0 (Triterpenes) |
| تواريخ الأحداث: | Date Created: 20180428 Date Completed: 20181017 Latest Revision: 20231213 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7992109 |
| DOI: | 10.1002/ptr.6091 |
| PMID: | 29701283 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1099-1573 |
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| DOI: | 10.1002/ptr.6091 |