دورية أكاديمية
أعرض في EDS

Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children.

التفاصيل البيبلوغرافية
العنوان: Association between genetic polymorphisms in DEFB1 and microRNA202 with caries in two groups of Brazilian children.
المؤلفون: Oliveira DSB; Department of Clinic and Surgery, School of Dentistry, Federal University of Alfenas, Minas Gerais, Brazil; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Ribeirão Preto, University of São Paulo, Brazil., Segato RAB; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Ribeirão Preto, University of São Paulo, Brazil., Oliveira S; Amazonas State University, Amazonas, Brazil., Dutra ALT; Amazonas State University, Amazonas, Brazil., Santos ASD; Amazonas State University, Amazonas, Brazil., Praxedes ADN; Amazonas State University, Amazonas, Brazil., Belém LC; Amazonas State University, Amazonas, Brazil., Antunes LA; Clinical Research Unit, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Department of Specific Formation, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil., Lips A; Clinical Research Unit, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Nelson-Filho P; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Ribeirão Preto, University of São Paulo, Brazil., da Silva LAB; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Ribeirão Preto, University of São Paulo, Brazil., Alves GG; Clinical Research Unit, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Antunes LS; Clinical Research Unit, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil; Department of Specific Formation, School of Dentistry of Nova Friburgo, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil., Küchler EC; Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, Ribeirão Preto, University of São Paulo, Brazil. Electronic address: daniela.oliveira@unifal-mg.edu.br.
المصدر: Archives of oral biology [Arch Oral Biol] 2018 Aug; Vol. 92, pp. 1-7. Date of Electronic Publication: 2018 Apr 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford : Pergamon Press
Original Publication: Oxford, New York [etc.] Pergamon Press.
مواضيع طبية MeSH: Polymorphism, Single Nucleotide*, Dental Caries/*genetics , MicroRNAs/*genetics , beta-Defensins/*genetics, Alleles ; Brazil ; Child ; Female ; Genotype ; Humans ; Male ; Real-Time Polymerase Chain Reaction
مستخلص: Objective: This replication study aimed to evaluate an association between caries experience and polymorphisms in DEFB1 and miRNA202 in two different Brazilian groups.
Design: The population consisted in 312 Brazilian children. Genomic DNA for was extracted from buccal cells isolated from saliva. The genotyping analysis of the polymorphisms in DEFB1 and miRNA202 was performed by real-time polymerase chain reactions. The associations between caries experience, genotype and allele distribution was performed, with an alpha of 0.05.
Results: A statistical significant difference was observed between allele distribution and the polymorphism rs12355840 in the miRNA202 for permanent dentition in the Manaus group, in which individuals that carry the allele C had almost three times more chance to have caries (p = .021; OR = 2.7, 95% CI = 1.1-6.7). In the Ribeirão Preto group there was a statistical significant difference for the polymorphism rs11362 in the DEFB1 for both dentition in alleles (p = .043) and genotype (p = .020) distributions. The T allele increased in two times the chance to have caries (OR = 2.03; 95% CI = 1.05-4.07).
Conclusion: In conclusion, the allelic distribution of the polymorphism rs12355840 in miRNA202 was associated with caries experience in the Manaus group. In the Ribeirão Preto group, the allelic and genotypic distributions in the polymorphism rs11362 in DEFB1 were associated with caries experience.
(Copyright © 2018. Published by Elsevier Ltd.)
فهرسة مساهمة: Keywords: Beta-defensins; Caries; Genetic polymorphisms; miRNA
المشرفين على المادة: 0 (DEFB1 protein, human)
0 (MicroRNAs)
0 (beta-Defensins)
تواريخ الأحداث: Date Created: 20180505 Date Completed: 20181211 Latest Revision: 20181211
رمز التحديث: 20231215
DOI: 10.1016/j.archoralbio.2018.04.010
PMID: 29727722
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1506
DOI:10.1016/j.archoralbio.2018.04.010