دورية أكاديمية
Clinical lymph node staging in colorectal cancer; a flip of the coin?
| العنوان: | Clinical lymph node staging in colorectal cancer; a flip of the coin? |
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| المؤلفون: | Brouwer NPM; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. Electronic address: nelleke.brouwer@radboudumc.nl., Stijns RCH; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Lemmens VEPP; Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands; Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands., Nagtegaal ID; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Beets-Tan RGH; Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands., Fütterer JJ; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands., Tanis PJ; Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands., Verhoeven RHA; Department of Research, Netherlands Comprehensive Cancer Organization (IKNL), Utrecht, The Netherlands., de Wilt JHW; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands. |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2018 Aug; Vol. 44 (8), pp. 1241-1246. Date of Electronic Publication: 2018 Apr 17. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Neoplasm Staging* , Registries*, Colorectal Neoplasms/*diagnosis , Lymph Nodes/*pathology , Population Surveillance/*methods, Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/secondary ; Humans ; Incidence ; Infant ; Infant, Newborn ; Lymphatic Metastasis/diagnosis ; Middle Aged ; Netherlands/epidemiology ; Predictive Value of Tests ; Retrospective Studies ; Sex Distribution ; Survival Rate/trends ; Young Adult |
| مستخلص: | Background: This study aims to provide insight in the quality of current daily practice in clinical lymph node staging in colorectal cancer (CRC) in the Netherlands. Methods: Data of the nationwide population-based Netherlands Cancer Registry between 2003 and 2014 were used to analyze lymph node staging for cM0 CRC patients. Accuracy of clinical lymph node staging was calculated for the period 2011-2014. Analyses were performed for patients without preoperative treatment or treated with short-course radiotherapy (SCRT) followed by resection. Results: 100,211 patients were included for analysis. The proportion clinically positive lymph nodes increased significantly between 2003 and 2014 (6%-22% for colon cancer; 7%-53% for rectal cancer). The proportion histological positive lymph nodes remained stable (±35% colon, ±33% rectum). Data from 2011 to 2014 yielded a sensitivity, specificity, positive and negative predictive value of 41%, 84%, 59% and 71% for colon cancer, respectively (n = 21,629). This was 38%, 87%, 56%, 76% for rectal cancer without SCRT, (n = 2178) and 56%, 67%, 47% and 75% for rectal cancer with SCRT (n = 3401), respectively. Conclusion: Accuracy of clinical lymph node staging in colorectal cancer patients is about as accurate as flipping a coin. This may lead to overtreatment of rectal cancer patients. Acceptable specificity and NPV limit the risk of undertreatment. (Copyright © 2018. Published by Elsevier Ltd.) |
| فهرسة مساهمة: | Keywords: Accuracy; Chemoradiotherapy; Colorectal cancer; Lymph node metastasis; Staging |
| تواريخ الأحداث: | Date Created: 20180510 Date Completed: 20180727 Latest Revision: 20180727 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ejso.2018.04.008 |
| PMID: | 29739638 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2018.04.008 |