دورية أكاديمية
Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response.
العنوان: | Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response. |
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المؤلفون: | Cardia GFE; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Silva-Filho SE; College of Health Sciences, Federal University of Grande Dourados, Dourados, MS, Brazil., Silva EL; Department of Chemistry, State University of Maringá, Maringá, PR, Brazil., Uchida NS; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Cavalcante HAO; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Cassarotti LL; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Salvadego VEC; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Spironello RA; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Bersani-Amado CA; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil., Cuman RKN; Department of Pharmacology and Therapeutics, State University of Maringá, Maringá, PR, Brazil. |
المصدر: | Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2018 Mar 18; Vol. 2018, pp. 1413940. Date of Electronic Publication: 2018 Mar 18 (Print Publication: 2018). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2011- : New York, NY : Hindawi Pub. Original Publication: Oxford, UK : Oxford University Press, c2004- |
مستخلص: | Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μ g/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro . The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine. |
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تواريخ الأحداث: | Date Created: 20180511 Latest Revision: 20201001 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC5878871 |
DOI: | 10.1155/2018/1413940 |
PMID: | 29743918 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1741-427X |
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DOI: | 10.1155/2018/1413940 |