دورية أكاديمية
Efficacy of Alpha Glucosidase Inhibitor from Marine Actinobacterium in the Control of Postprandial Hyperglycaemia in Streptozotocin (STZ) Induced Diabetic Male Albino Wister Rats.
| العنوان: | Efficacy of Alpha Glucosidase Inhibitor from Marine Actinobacterium in the Control of Postprandial Hyperglycaemia in Streptozotocin (STZ) Induced Diabetic Male Albino Wister Rats. |
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| المؤلفون: | Kumar SRS; Molecular and Microbiology Research Laboratory, Environmental Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore - 632 014, Tamilnadu, India., Rao KVB; Molecular and Microbiology Research Laboratory, Environmental Biotechnology Division, School of Bio Sciences and Technology, VIT University, Vellore - 632 014, Tamilnadu, India. |
| المصدر: | Iranian journal of pharmaceutical research : IJPR [Iran J Pharm Res] 2018 Winter; Vol. 17 (1), pp. 202-214. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Brieflands Country of Publication: Netherlands NLM ID: 101208407 Publication Model: Print Cited Medium: Print ISSN: 1735-0328 (Print) Linking ISSN: 17266882 NLM ISO Abbreviation: Iran J Pharm Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2022- : ['s-Hertogenbosch, The Netherlands] : Brieflands Original Publication: Tehran : School of Pharmacy, Shaheed Beheshti University of Medical Sciences and Health Services |
| مستخلص: | The current study was carried out to evaluate the in-vitro and in-vivo efficiency of alpha glucosidase inhibitor of marine actinobacteria in the control of postprandial hyperglycaemia. Soil samples were collected from salterns, coastal area in Kothapatnam, Ongole, Andhra Pradesh, India. Among the actinobacterial isolates tested for yeastα-glucosidase inhibitory activity, only three isolates showed prominent inhibition. The patient isolate was selected and identified as Streptomyces coelicoflavus SRBVIT13 using 16S r-RNA gene sequencing. In in-vitro studies, the chloroform extract of Streptomyces coelicoflavus SRBVIT13 showed significant enzyme inhibitory activity against yeast and mammalian α-glucosidaseenzymes. In animal studies, the oral ingestion of chloroform extract (600 mg/kg) of S. coelicoflavus SRBVIT13 in maltose and sucrose loaded diabetic rats, showed significant regulation of postprandial blood glucose by 82.25% and a 77.25% reduction, respectively. The lead compound from S. coelicoflavus SRBVIT13 was isolated, purified, characterized, and identified by stranded analytical techniques as 2-t-butyl-5-chloromethyl-3-methyl-4-oxoimidazolidine-1-carboxylic acid, t-butyl ester. The results obtained in the present study are promising and the bioactive compound from S. coelicoflavus SRBVIT13 may be considered as a potential agent in regulating the postprandial hyperglycaemia. |
| References: | Nutr Metab (Lond). 2011 Jun 29;8(1):46. (PMID: 21711570) J Antibiot (Tokyo). 2005 Jan;58(1):1-26. (PMID: 15813176) Microbiol Rev. 1980 Jun;44(2):230-51. (PMID: 6991900) Diabetes Care. 2005 Jan;28(1):154-63. (PMID: 15616251) Antonie Van Leeuwenhoek. 2005 Jan;87(1):59-63. (PMID: 15726292) Metabolism. 2006 Jun;55(6):832-41. (PMID: 16713445) Diabetes Care. 2009 Sep;32(9):1721-6. (PMID: 19502543) PLoS One. 2014 Mar 11;9(3):e90972. (PMID: 24618707) Diabetes Obes Metab. 2001 Aug;3 Suppl 1:3-10. (PMID: 11683853) Biochem J. 1961 Nov;81:411-8. (PMID: 13883115) Drug Discov Today. 2003 Jun 15;8(12 ):536-44. (PMID: 12821301) Nature. 2001 Dec 13;414(6865):782-7. (PMID: 11742409) Nanomedicine. 2013 Oct;9(7):951-60. (PMID: 23434675) Indian J Microbiol. 2008 Dec;48(4):410-31. (PMID: 23100742) Nat Rev Endocrinol. 2011 Nov 08;8(4):228-36. (PMID: 22064493) Diabetes. 2003 Mar;52(3):741-50. (PMID: 12606516) Arch Intern Med. 2003 Jun 9;163(11):1306-16. (PMID: 12796066) Mar Drugs. 2009;7(1):24-44. (PMID: 19370169) Annu Rev Microbiol. 1983;37:189-216. (PMID: 6357051) Cellscience. 2006 Apr 30;2(4):100-131. (PMID: 16892160) N Engl J Med. 1992 Jan 2;326(1):22-9. (PMID: 1727062) Am J Physiol Endocrinol Metab. 2004 Dec;287(6):E1049-56. (PMID: 15304374) Trends Immunol. 2004 Jan;25(1):4-7. (PMID: 14698276) Mar Biotechnol (NY). 2004 May-Jun;6(3):193-8. (PMID: 15129325) Diabetes Care. 2009 Nov;32 Suppl 2:S322-5. (PMID: 19875573) Lancet. 2008 Jun 28;371(9631):2153-6. (PMID: 18586159) Res Exp Med (Berl). 1979 Apr 23;175(1):81-6. (PMID: 375342) Asian Pac J Trop Biomed. 2012 Jun;2(6):469-73. (PMID: 23569952) Lancet. 2005 Apr 9-15;365(9467):1333-46. (PMID: 15823385) |
| فهرسة مساهمة: | Keywords: Diabetes mellitus; Marine actinobacteria; Postprandial; Salterns; Streptomyces; α-glucosidase |
| تواريخ الأحداث: | Date Created: 20180515 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5937091 |
| PMID: | 29755552 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1735-0328 |
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