دورية أكاديمية
[Effects of ginkgo biloba extract combined with glucocorticoid on olfactory function and inflammatory cytokines in mice with allergic rhinitis].
| العنوان: | [Effects of ginkgo biloba extract combined with glucocorticoid on olfactory function and inflammatory cytokines in mice with allergic rhinitis]. |
|---|---|
| المؤلفون: | Wu C; Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University Beijing,100029,China., Wei YX; Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University Beijing,100029,China., Pinto JM; Section of Otolaryngology-Head and Neck Surgery,Department of Surgery,The University of Chicago., Tian J; Department of Otolaryngology Head and Neck Surgery,Shanxi Medical University., Yuan XD; Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University Beijing,100029,China., Zhan XJ; Department of Otolaryngology Head and Neck Surgery,Beijing Anzhen Hospital,Capital Medical University Beijing,100029,China. |
| المصدر: | Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery [Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi] 2018 Jan 20; Vol. 32 (2), pp. 113-117. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu Country of Publication: China NLM ID: 101303164 Publication Model: Print Cited Medium: Print ISSN: 2096-7993 (Print) Linking ISSN: 20967993 NLM ISO Abbreviation: Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wuhan Shi : Lin chuang er bi yan hou tou jing wai ke za zhi bain ji bu |
| مواضيع طبية MeSH: | Glucocorticoids/*pharmacology , Plant Extracts/*pharmacology , Rhinitis, Allergic/*drug therapy, Animals ; Cytokines/metabolism ; Disease Models, Animal ; Ginkgo biloba ; Glucocorticoids/administration & dosage ; Mice ; Mice, Inbred BALB C ; Plant Extracts/administration & dosage ; Rhinitis, Allergic/immunology |
| مستخلص: | Objective: To determine whether ginkgo biloba extract(GBE)combined with dexamethasone(DEX)plays a role in the treatment of allergic rhinitis-related olfactory dysfunction using an animal model. Method: Six week old BALB/C mice were sensitized and challenged with ovalbumin.30 sensitized mice were divided into three groups:Group 1 was given high-dose GBE and DEX(n=10);Group 2 was given low dose GBE and DEX(n=10);Group 3 was given DEX alone(n=10).We assessed the histology of the olfactory mucosa and serum IL-4,IFN-γ,and caspase 1. Result: A significant higher fraction of mice in group 1 could find the food pellet within300 scompared to group 3( P <0.05).Caspase-1 levels improved during the second week compared with the first week in each group.IFN-γlevels were significantly lower during the second week compared with the first week( P <0.05,all).IL-4 levels also were significantly lower during the second week compared with the first week in all groups except those receiving DEX alone.IFN-γ/IL-4 levels in each group were significantly lower during the second week compared with the first week( P <0.05,all). Conclusion: In this animal model of allergic rhinitis-related olfactory dysfunction,the addition of ginkgo biloba extract to dexamethasone have a better anti-inflammatory effect,which can partly improve the therapeutic effect on olfactory dysfunction caused by allergic rhinitis. |
| فهرسة مساهمة: | Keywords: ginkgo biloba extract; olfactory dysfunction; rhinitis, allergic |
| المشرفين على المادة: | 0 (Cytokines) 0 (Glucocorticoids) 0 (Plant Extracts) 19FUJ2C58T (Ginkgo biloba extract) |
| تواريخ الأحداث: | Date Created: 20180515 Date Completed: 20181211 Latest Revision: 20211204 |
| رمز التحديث: | 20221213 |
| DOI: | 10.13201/j.issn.1001-1781.2018.02.009 |
| PMID: | 29757557 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2096-7993 |
|---|---|
| DOI: | 10.13201/j.issn.1001-1781.2018.02.009 |