دورية أكاديمية
Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill.
| العنوان: | Valproic acid induces three novel cytotoxic secondary metabolites in Diaporthe sp., an endophytic fungus from Datura inoxia Mill. |
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| المؤلفون: | Sharma V; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India., Singamaneni V; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Sharma N; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India., Kumar A; Instrumentation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Arora D; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India., Kushwaha M; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India., Bhushan S; Cancer Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Indian Pharmacopoeia Commission, Ministry of Health & Family Welfare, Ghaziabad, UP-201002, India., Jaglan S; Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India. Electronic address: sundeepjaglan@iiim.ac.in., Gupta P; Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), CSIR, New Delhi 110025, India. Electronic address: guptap@iiim.ac.in. |
| المصدر: | Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Jul 01; Vol. 28 (12), pp. 2217-2221. Date of Electronic Publication: 2018 Apr 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford ; New York : Pergamon Press, c1991- |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Ascomycota/*chemistry , Datura/*microbiology , Peptides, Cyclic/*pharmacology , Valproic Acid/*pharmacology, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/metabolism ; Ascomycota/growth & development ; Ascomycota/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Datura/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Escherichia coli/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Conformation ; Peptides, Cyclic/chemistry ; Peptides, Cyclic/metabolism ; Pseudomonas aeruginosa/drug effects ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Valproic Acid/chemistry |
| مستخلص: | Addition of the valproic acid (histone deacetylases inhibitor) to a culture of an endophytic fungus Diaporthe sp. harbored from Datura inoxia significantly altered its secondary metabolic profile and resulted in the isolation of three novel compounds, identified as xylarolide A (1), diportharine A (2) and xylarolide B (3) along with one known compound xylarolide (4). The structures of all the compounds (1-4) were determined by detailed analysis of 1D and 2D NMR spectroscopic data. The relative configurations of compounds 1-3 were determined with the help of NOESY data and comparison of optical rotations with similar compounds with established stereochemistry. All the isolated compounds were screened for antibacterial, antioxidant and cytotoxic activities. Xylarolide A (1) and xylarolide (4) displayed significant growth inhibition of MIAPaCa-2 with an IC (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Anti-oxidant activity; Cytotoxic activity; Datura inoxia; Diaporthe sp.; Endophytic fungi; MIA-Pa-Ca-2-cells; Xylarolide |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents) 0 (Peptides, Cyclic) 0 (xylarotide A) 0 (xylarotide B) 614OI1Z5WI (Valproic Acid) |
| تواريخ الأحداث: | Date Created: 20180516 Date Completed: 20190128 Latest Revision: 20190128 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.bmcl.2018.04.018 |
| PMID: | 29759727 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1464-3405 |
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| DOI: | 10.1016/j.bmcl.2018.04.018 |