دورية أكاديمية
أعرض في EDS

Patient reported adverse events among epileptic patients taking antiepileptic drugs.

التفاصيل البيبلوغرافية
العنوان: Patient reported adverse events among epileptic patients taking antiepileptic drugs.
المؤلفون: Ayalew MB; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine & Health Sciences, University of Gondar, Gondar, Ethiopia., Muche EA; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine & Health Sciences, University of Gondar, Gondar, Ethiopia.
المصدر: SAGE open medicine [SAGE Open Med] 2018 May 04; Vol. 6, pp. 2050312118772471. Date of Electronic Publication: 2018 May 04 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 101624744 Publication Model: eCollection Cited Medium: Print ISSN: 2050-3121 (Print) Linking ISSN: 20503121 NLM ISO Abbreviation: SAGE Open Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : SAGE Publications
مستخلص: Objective: The aim of this study was to assess patient reported adverse events and associated factors among epileptic patients taking antiepileptic drugs on follow-up at University of Gondar Referral Hospital.
Methods: Cross-sectional study was done on 354 adult epileptic patients. Patients who were on antiepileptic drugs for epilepsy treatment for less than a year, those who were below 18 years old, patients with incomplete information on the chart and those who were involuntary or uncooperative were excluded from the study. Data were entered in to SPSS version 20.0 for analysis. Bivariate and multivariate binary logistic regression analysis was done to see factors associated with antiepileptic drugs adverse effect. Level of statistical significance was declared at p ≤ 0.05.
Result: Generalized tonic clonic seizure was the most common (86.2%) type of epilepsy. A total of 79 adverse events were reported. The most frequently encountered adverse events were fatigue (5.08%), gastrointestinal disturbance (4.24%) and sedation/depression (4.24%). Adverse drug effect of antiepileptic drugs was significantly associated with illiterate educational status, increased number of antiepileptic drugs, no seizure during last follow-up and last year, and 1-5 seizures for the last year.
Conclusion: About one-sixth of epileptic patients reported adverse drug effects. Adverse drug effects were more commonly seen in patients with low educational status, increased number of antiepileptic drugs, absence of seizure during last follow-up and last year, and 1-5 seizures for the last year. So clinicians should give emphasis for patients with these characteristics to counsel on how to minimize or prevent adverse drug events from antiepileptic drugs or giving reassurance about it if it is minor.
Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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فهرسة مساهمة: Keywords: Adverse event; antiepileptic drug; epilepsy; seizure; side effect
تواريخ الأحداث: Date Created: 20180516 Latest Revision: 20220317
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5946606
DOI: 10.1177/2050312118772471
PMID: 29760918
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-3121
DOI:10.1177/2050312118772471