دورية أكاديمية
أعرض في EDS

Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche.

التفاصيل البيبلوغرافية
العنوان: Postnatal testis development in the collared peccary (Tayassu tajacu), with emphasis on spermatogonial stem cells markers and niche.
المؤلفون: Lara NLEM; Laboratory of Cellular Biology, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Costa GMJ; Laboratory of Cellular Biology, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Avelar GF; Laboratory of Cellular Biology, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Guimarães DA; Laboratory of Animal Reproduction, Biological Sciences Institute, Federal University of Pará, Belém, PA, Brazil., França LR; Laboratory of Cellular Biology, Department of Morphology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; National Institute for Amazonian Research, Manaus, AM, Brazil. Electronic address: lrfranca@inpa.gov.br.
المصدر: General and comparative endocrinology [Gen Comp Endocrinol] 2019 Mar 01; Vol. 273, pp. 98-107. Date of Electronic Publication: 2018 May 12.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-6840 (Electronic) Linking ISSN: 00166480 NLM ISO Abbreviation: Gen Comp Endocrinol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Academic Press
Original Publication: New York.
مواضيع طبية MeSH: Stem Cell Niche*, Artiodactyla/*growth & development , Biomarkers/*metabolism , Spermatogonia/*cytology , Stem Cells/*metabolism , Testis/*growth & development, Animals ; Body Weight ; Hormones/metabolism ; Male ; Organ Size ; Phenotype ; Seminiferous Tubules/metabolism ; Sertoli Cells/metabolism ; Spermatogenesis ; Spermatogonia/metabolism ; Testis/anatomy & histology ; Testis/metabolism
مستخلص: Collared peccaries (Tayassu tajacu) present a unique testis cytoarchitecture, where Leydig cells (LC) are mainly located in cords around the seminiferous tubules (ST) lobes. This peculiar arrangement is very useful to better investigate and understand the role of LC in spermatogonial stem cells (SSCs) biology and niche. Recent studies from our laboratory using adult peccaries have shown that the undifferentiated type A spermatogonia (A und or SSCs) are preferentially located in ST regions adjacent to the intertubular compartment without LC. Following these studies, our aims were to investigate the collared peccary postnatal testis development, from birth to adulthood, with emphasis on the establishment of LC cytoarchitecture and the SSCs niche. Our findings demonstrated that the unique LC cytoarchitecture is already present in the neonate peccary's testis, indicating that this arrangement is established during fetal development. Based on the most advanced germ cell type present at each time period evaluated, puberty (the first sperm release in the ST lumen) in this species was reached at around one year of age, being preceded by high levels of estradiol and testosterone and the end of Sertoli cell proliferation. Almost all gonocytes and SSCs expressed Nanos1, Nanos2 and GFRA1. The analysis of SSCs preferential location indicated that the establishment of SSCs niche is coincident with the occurrence of puberty. Taken together, our findings reinforced and extended the importance of the collared peccary as an animal model to investigate testis function in mammals, particularly the aspects related to testis organogenesis and the SSCs biology and niche.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Collared peccary; Leydig cell; Puberty; Sertoli cell; Spermatogonial stem cell niche; Testis development
المشرفين على المادة: 0 (Biomarkers)
0 (Hormones)
تواريخ الأحداث: Date Created: 20180516 Date Completed: 20190408 Latest Revision: 20190408
رمز التحديث: 20240628
DOI: 10.1016/j.ygcen.2018.05.013
PMID: 29763586
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-6840
DOI:10.1016/j.ygcen.2018.05.013