دورية أكاديمية
أعرض في EDS

Tristemma hirtum and Five Other Cameroonian Edible Plants with Weak or No Antibacterial Effects Modulate the Activities of Antibiotics against Gram-Negative Multidrug-Resistant Phenotypes.

التفاصيل البيبلوغرافية
العنوان: Tristemma hirtum and Five Other Cameroonian Edible Plants with Weak or No Antibacterial Effects Modulate the Activities of Antibiotics against Gram-Negative Multidrug-Resistant Phenotypes.
المؤلفون: Nguenang GS; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Mbaveng AT; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Fankam AG; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Manekeng HT; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Nayim P; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Wamba BEN; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Kuete V; Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon.
المصدر: TheScientificWorldJournal [ScientificWorldJournal] 2018 Mar 22; Vol. 2018, pp. 7651482. Date of Electronic Publication: 2018 Mar 22 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: United States NLM ID: 101131163 Publication Model: eCollection Cited Medium: Internet ISSN: 1537-744X (Electronic) Linking ISSN: 1537744X NLM ISO Abbreviation: ScientificWorldJournal Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Hindawi Publishing Corporation
Original Publication: Boynton Beach, FL : Scientific World, Inc., c2001-
مواضيع طبية MeSH: Anti-Infective Agents/*pharmacology , Drug Resistance, Multiple, Bacterial/*drug effects , Gram-Negative Bacteria/*drug effects , Melastomataceae/*chemistry , Plant Extracts/*pharmacology , Plants, Edible/*chemistry, Microbial Sensitivity Tests ; Phytochemicals/chemistry
مستخلص: In order to contribute to the fight against infectious diseases, the in vitro antibacterial activity and the antibiotic-potentiating effects of Tristemma hirtum and five other Cameroonian edible plants have been evaluated against Gram-negative multidrug-resistant (MDR) phenotypes. The microdilution method was used to evaluate the bacterial susceptibility of the extracts and their combination to common antibiotics. The phytochemical screening of the extracts was carried out according to standard methods. Phytochemical analysis of the extracts revealed the presence of alkaloids, triterpenes, steroids, and polyphenols, including flavonoids in most of the tested extracts. The entire tested extracts showed moderate (512  μ g/mL ≤ MIC ≤ 2048  μ g/mL) to weak (MIC > 2048  μ g/mL) antibacterial activities against the tested bacteria. Furthermore, extracts of leaf of Tristemma hirtum and pericarp s of Raphia hookeri (at their MIC/2 and MIC/4) strongly potentiated the activities of all antibiotics used in the study, especially those of chloramphenicol (CHL), ciprofloxacin (CIP), kanamycin (KAN), and tetracycline (TET) against 70% (7/10) to 100% (10/10) of the tested MDR bacteria, with the modulating factors ranging from 2 to 128. The results of this study suggest that extracts from leaves of Tristemma hirtum and pericarps of Raphia hookeri can be sources of plant-derived products with antibiotic modifying activity.
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المشرفين على المادة: 0 (Anti-Infective Agents)
0 (Phytochemicals)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20180517 Date Completed: 20180926 Latest Revision: 20240322
رمز التحديث: 20240322
مُعرف محوري في PubMed: PMC5885400
DOI: 10.1155/2018/7651482
PMID: 29765275
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-744X
DOI:10.1155/2018/7651482