دورية أكاديمية
أعرض في EDS

Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial and antioxidant activities of triterpenoid and phenolic derivatives from two Cameroonian Melastomataceae plants: Dissotis senegambiensis and Amphiblemma monticola.
المؤلفون: Nzogong RT; Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Ndjateu FST; Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.; H.E.J Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakistan., Ekom SE; Laboratory of Microbiology and Antimicrobial substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Fosso JM; Laboratory of Microbiology and Antimicrobial substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Awouafack MD; Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan., Tene M; Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. mtene2001@yahoo.fr., Tane P; Laboratory of Natural Products Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Morita H; Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama, 930-0194, Japan., Choudhary MI; H.E.J Research Institute of Chemistry, University of Karachi, -75270, Karachi, Pakistan., Tamokou JD; Laboratory of Microbiology and Antimicrobial substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. jtamokou@yahoo.fr.
المصدر: BMC complementary and alternative medicine [BMC Complement Altern Med] 2018 May 16; Vol. 18 (1), pp. 159. Date of Electronic Publication: 2018 May 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088661 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6882 (Electronic) Linking ISSN: 14726882 NLM ISO Abbreviation: BMC Complement Altern Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001-2019]
مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Antioxidants/*pharmacology , Melastomataceae/*chemistry , Plant Extracts/*pharmacology, Animals ; Anti-Bacterial Agents/chemistry ; Antioxidants/chemistry ; Biphenyl Compounds ; Cameroon ; Erythrocytes ; Hemolysis/drug effects ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Phenols/chemistry ; Phenols/pharmacology ; Picrates ; Plant Extracts/chemistry ; Plant Extracts/toxicity ; Rats ; Triterpenes/chemistry ; Triterpenes/pharmacology
مستخلص: Background: Antimicrobial resistance is a serious threat against humankind and the search for new therapeutics is needed. This study aims to investigate the antimicrobial and antioxidant activities of ethanol extracts and compounds isolated from Dissotis senegambiensis and Amphiblemma monticola, two Cameroonian Melastomataceae species traditionally used for the treatment of fever, malaria and infectious diseases.
Methods: The plant extracts were prepared by maceration in ethanol. Standard chromatographic and spectroscopic methods were used to isolate and identify fourteen compounds from the two plant species [1-6 (from D. senegambiensis), 3, 4 and 7-14 (from A. monticola)]. A two-fold serial micro-dilution method was used to determine the minimum inhibitory concentration (MIC) against four bacterial strains including two resistant bacterial strains, methicillin resistant S. aureus (MRSA3) and methicillin resistant S. aureus (MRSA4) and three yeast strains.
Results: The fractionation of EtOH extracts afforded fourteen compounds belonging to triterpenoid and phenolic derivatives. The ethanol extracts, compounds 3, 5-8, 10 and the mixture of 10 + 12 were active against all the tested bacterial and fungal species. Compound 7 (MIC = 16-32 μg/mL) and 10 (MIC = 8-16 μg/mL) displayed the largest antibacterial and antifungal activities, respectively. Compounds 7, 10 and the mixture of 10 + 12 showed prominent antibacterial activity against methicillin- resistant S. aureus (MRSA) which is in some cases equal to that of ciprofloxacin used as reference antibacterial drug. Compound 8 also showed high radical-scavenging activities and ferric reducing power when compared with vitamin C and butylated hydroxytoluene used as reference antioxidants. The tested samples were non-toxic to normal cells highlighting their good selectivity.
Conclusions: The result of this investigation reveals the potential of D. senegambiensis and A. monticola as well as the most active compounds in the search for new antimicrobial and antioxidant agents. So, further investigations are needed.
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فهرسة مساهمة: Keywords: Amphiblemma monticola; Antibacterial; Antifungal; Dissotis senegambiensis; Melastomataceae; Methicillin-resistant S. aureus; Phenolics; Triterpenoids
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Antioxidants)
0 (Biphenyl Compounds)
0 (Phenols)
0 (Picrates)
0 (Plant Extracts)
0 (Triterpenes)
DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
تواريخ الأحداث: Date Created: 20180518 Date Completed: 20180629 Latest Revision: 20181114
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5956543
DOI: 10.1186/s12906-018-2229-2
PMID: 29769064
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6882
DOI:10.1186/s12906-018-2229-2