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Ozone therapy prevents the onset of dysplasia in HPV16-transgenic mice-A pre-clinical efficacy and safety analysis.

التفاصيل البيبلوغرافية
العنوان: Ozone therapy prevents the onset of dysplasia in HPV16-transgenic mice-A pre-clinical efficacy and safety analysis.
المؤلفون: Peirone C; Department of Veterinary Sciences, UTAD, Vila Real, Portugal. Electronic address: cecilia_peirone@yahoo.com.ar., Mestre VF; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal. Electronic address: vero.mestre11@gmail.com., Medeiros-Fonseca B; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal., Colaço B; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Zootechnics Department, UTAD, Vila Real, Portugal., Pires MJ; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal., Martins T; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal., Gil da Costa RM; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Laboratory for Process Engineering Environment Biotechnology and Energy (LEPABE) Chemical Engineering Department, Faculty of Engineering, University of Porto (FEUP), Porto, Portugal; Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO-Porto), Porto, Portugal. Electronic address: rmcosta@fe.up.pt., Neuparth MJ; Advanced Polytechnic and University Cooperative (CESPU), Institute of Research and Advanced Training in Health Sciences and Technologies (IINFACTS), Gandra, Portugal; Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sports, University of Porto, Porto, Portugal., Medeiros R; Molecular Oncology and Viral Pathology Group, IPO-Porto Research Center (CI-IPOP), Portuguese Institute of Oncology of Porto (IPO-Porto), Porto, Portugal; Faculty of Medicine, University of Porto (FMUP), Porto, Portugal; CEBIMED, Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal; LPCC Research Department, Portuguese League against Cancer (NRNorte), Porto, Portugal., Bastos MMSM; Laboratory for Process Engineering Environment Biotechnology and Energy (LEPABE) Chemical Engineering Department, Faculty of Engineering, University of Porto (FEUP), Porto, Portugal., Marques-Magallanes JA; Critical Care Department, University Hospital of Braga, Braga, Portugal., Oliveira PA; Department of Veterinary Sciences, UTAD, Vila Real, Portugal; Center for the Research and Technology of Agro-Environmental and Biological Sciences (CITAB), University of Trás-os-Montes and Alto Douro (UTAD), Vila Real, Portugal.
المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Aug; Vol. 104, pp. 275-279. Date of Electronic Publication: 2018 May 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE
أسماء مطبوعة: Publication: Paris : Editions Scientifiques Elsevier
Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982-
مواضيع طبية MeSH: Human papillomavirus 16/*pathogenicity , Neoplasms/*drug therapy , Ozone/*pharmacology , Skin Diseases/*drug therapy, Animals ; Disease Progression ; Female ; Mice ; Mice, Transgenic ; Neoplasms/virology ; Papillomavirus Infections/complications ; Rabbits ; Skin/drug effects ; Skin/virology ; Skin Diseases/virology ; Treatment Outcome
مستخلص: Infection with high-risk human papillomavirus (HPV), most often HPV16, is associated with the development of anogenital and oropharyngeal cancers. Recently, ozone therapy was reported to have considerable efficacy against rabbit VX2 tumors, induced by the cottontail rabbit papillomavirus. The present study aims to determine whether similar results can be obtained in HPV16-transgenic mice, possibly paving the way for new therapeutic options against HPV-induced cancers. HPV16-transgenic and wild-type, female, 20 weeks-old mice were injected intraperitoneally with medical O 3 /O 2 (80░mL/kg, at O 3 50░μg/mL), once a day, for 5 consecutive days. The animals were sacrificed at 25 weeks-old, and skin samples were analyzed histologically to study tumour progression. Blood and internal organ samples were used to study toxicological parameters. 85.7% of untreated transgenic mice showed dysplastic skin lesions, compared with 28.6% of O 3 -treated mice. This was associated with a marked reduction of dermal inflammation associated with those lesions. No significant changes were observed in any toxicological parameters. These preliminary results support the hypothesis that O 3 therapy is effective against papillomavirus-induced lesions, particularly against those induced by the most common high-risk virus, HPV16. Further studies are needed to confirm the mechanisms underlying these effects.
(Copyright © 2018 Elsevier Masson SAS. All rights reserved.)
فهرسة مساهمة: Keywords: Cancer; HPV16; Human papillomavirus; Mouse; Ozone; Pre-clinical
المشرفين على المادة: 66H7ZZK23N (Ozone)
تواريخ الأحداث: Date Created: 20180519 Date Completed: 20181010 Latest Revision: 20181010
رمز التحديث: 20231215
DOI: 10.1016/j.biopha.2018.05.018
PMID: 29775895
قاعدة البيانات: MEDLINE
الوصف
تدمد:1950-6007
DOI:10.1016/j.biopha.2018.05.018