دورية أكاديمية
Cardiac autonomic modulation and long-term use of amiodarone in patients with chronic Chagasic cardiopathy.
| العنوان: | Cardiac autonomic modulation and long-term use of amiodarone in patients with chronic Chagasic cardiopathy. |
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| المؤلفون: | Fortes Silva HE; Division of Infectious Diseases, Internal Medicine Department, Triangulo Mineiro Federal University, Uberaba, MG, Brazil., de Almeida RS; Division of Infectious Diseases, Internal Medicine Department, Triangulo Mineiro Federal University, Uberaba, MG, Brazil., Silveira DB; Division of Infectious Diseases, Internal Medicine Department, Triangulo Mineiro Federal University, Uberaba, MG, Brazil., Llaguno M; Division of Infectious Diseases, Internal Medicine Department, Triangulo Mineiro Federal University, Uberaba, MG, Brazil., Resende LAPR; Department of Internal Medicine, Health Sciences Institute, Triangulo Mineiro Federal University, Uberaba, MG, Brazil., Dias da Silva VJ; Department of Physiology, Natural and Biological Sciences Institute, Triangulo Mineiro Federal University, Uberaba, MG, Brazil., Correia D; Division of Infectious Diseases, Internal Medicine Department, Triangulo Mineiro Federal University, Uberaba, MG, Brazil. |
| المصدر: | Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2018 Jul; Vol. 41 (7), pp. 788-798. Date of Electronic Publication: 2018 Jun 08. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Futura Pub. Co. Country of Publication: United States NLM ID: 7803944 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8159 (Electronic) Linking ISSN: 01478389 NLM ISO Abbreviation: Pacing Clin Electrophysiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Mount Kisco, N. Y. : Futura Pub. Co., c1978- |
| مواضيع طبية MeSH: | Amiodarone/*pharmacology , Anti-Arrhythmia Agents/*pharmacology , Autonomic Nervous System/*drug effects , Chagas Cardiomyopathy/*physiopathology , Heart Rate/*drug effects, Aged ; Amiodarone/therapeutic use ; Anti-Arrhythmia Agents/therapeutic use ; Arrhythmias, Cardiac/complications ; Arrhythmias, Cardiac/drug therapy ; Chagas Cardiomyopathy/complications ; Chronic Disease ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Time Factors |
| مستخلص: | Background: Patients with chronic Chagas cardiopathy (CCC), which may be associated with cardiac arrhythmias, frequently use amiodarone, an antiarrhythmic drug that, experimentally, appears to modulate the cardiac autonomic function. Objective: The present cross-sectional observational study aimed to evaluate autonomic cardiac modulation in patients with CCC undergoing chronic amiodarone therapy. Methods: Three groups were investigated: Group 1 included patients with CCC not treated with amiodarone (n = 27); Group 2 included patients with CCC with prolonged use (at least 6 months) of amiodarone (n = 16); and Group 3 included non-Chagasic control patients (n = 23). All patients underwent a complete clinical and laboratory assessment, followed by autonomic function tests, consisting of a basal continuous electrocardiogram in the resting supine position for 10 minutes, followed by a change the orthostatic posture for a further 5 minutes. Heart rate variability (HRV) parameters (median and interquartile interval) were quantified using linear methods in the time- and frequency-domains (autoregressive spectral analysis) and nonlinear methods, including symbolic analysis. Results: Patients with CCC using amiodarone had changes in HRV suggestive of an offset in the sympatho-vagal balance with a vagal modulation predominance (normalized HF, 49.7[27.4] vs 31.1[22.8] [P < 0.05]; and percentage 2V, 40.1 [14.6] vs 21.5 [13.4] [P < 0.05] vs untreated CCC group). These changes were further accompanied by increases in parameters indicative of greater complexity of HRV. Conclusions: The deviation in the sympatho-vagal balance and the increase in the complexity of HRV strongly suggest that amiodarone may have a cardioprotective effect, in addition to its antiarrhythmic effects, which could increase the survival of these patients. (© 2018 Wiley Periodicals, Inc.) |
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| فهرسة مساهمة: | Keywords: Chagas disease; amiodarone; cardiac autonomic modulation; heart rate variability |
| المشرفين على المادة: | 0 (Anti-Arrhythmia Agents) N3RQ532IUT (Amiodarone) |
| تواريخ الأحداث: | Date Created: 20180522 Date Completed: 20191212 Latest Revision: 20200108 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1111/pace.13384 |
| PMID: | 29781516 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1540-8159 |
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| DOI: | 10.1111/pace.13384 |