دورية أكاديمية
Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model.
| العنوان: | Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model. |
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| المؤلفون: | Contreras A; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, 2015 Linden Drive, Madison, WI, 53706, USA., Beems MV; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Tatar AJ; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Sen S; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Srinand P; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Suresh M; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, 2015 Linden Drive, Madison, WI, 53706, USA., Luther TK; VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI, 48105, USA.; Department of Surgery, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA., Cho CS; VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI, 48105, USA. cliffcho@med.umich.edu.; Department of Surgery, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA. cliffcho@med.umich.edu. |
| المصدر: | Journal for immunotherapy of cancer [J Immunother Cancer] 2018 May 29; Vol. 6 (1), pp. 41. Date of Electronic Publication: 2018 May 29. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : London, United Kingdom : BMJ Publishing Group Ltd. Original Publication: London : BioMed Central, 2013- |
| مواضيع طبية MeSH: | Adoptive Transfer/*methods , CD8-Positive T-Lymphocytes/*immunology , Immunologic Memory/*immunology , Immunotherapy/*methods , Melanoma/*immunology, Animals ; Disease Models, Animal ; Female ; Mice |
| مستخلص: | Background: Adoptive cell transfer (ACT) is a promising cancer immunotherapeutic strategy that remains ineffective for a large subset of patients. ACT with memory CD8+ T cells (T Methods: Splenocytes harvested from Ly5.1+/C57BL/6 mice during and after infection with lymphocytic choriomeningitis virus (LCMV) were used to generate bona fide effector and memory CD8+ T cells specific for the LCMV epitope peptide GP33. Congenic Ly5.2+/C57BL/6 mice were inoculated with B16F10 melanoma cells transfected to express very low levels of GP33, then treated with ACT 7 days later with GP33-specific T Results: Inhibition of melanoma growth was strongest in mice receiving combinatorial ACT. Although combinatorial ACT and memory ACT resulted in maximal intratumoral infiltration of CD8+ T cells, combinatorial ACT induced stronger infiltration of endogenous CD8+ T cells than T Conclusions: These findings suggest that a novel combinatorial approach that takes advantage of the unique and complementary strengths of tumor-specific T |
| References: | J Clin Invest. 2016 Jan;126(1):318-34. (PMID: 26657860) J Immunother. 2015 Feb-Mar;38(2):54-61. (PMID: 25658614) PLoS One. 2015 Jun 24;10(6):e0131242. (PMID: 26107883) Cell Rep. 2016 Feb 9;14 (5):1206-1217. (PMID: 26804903) Hum Gene Ther. 2008 May;19(5):496-510. (PMID: 18444786) Cancer Immunol Immunother. 2016 May;65(5):601-11. (PMID: 27011014) Clin Cancer Res. 2011 Jul 1;17(13):4550-7. (PMID: 21498393) Nat Rev Immunol. 2002 Apr;2(4):251-62. (PMID: 12001996) J Clin Invest. 2015 May;125(5):2090-108. (PMID: 25893604) J Clin Invest. 2005 Jun;115(6):1616-26. (PMID: 15931392) Immunity. 2007 Sep;27(3):393-405. (PMID: 17892848) Ann Surg Oncol. 2011 Dec;18(13):3848-57. (PMID: 21465311) J Immunol. 2003 Nov 15;171(10):5051-63. (PMID: 14607902) J Immunother. 2012 Nov-Dec;35(9):651-60. (PMID: 23090074) J Immunol. 2014 Jun 15;192(12):5451-8. (PMID: 24907378) Cell Immunol. 2011;271(1):104-9. (PMID: 21741629) Cancer Immunol Immunother. 2013 Jan;62(1):149-59. (PMID: 22865267) Cancer Immunol Immunother. 2009 Oct;58(10):1565-76. (PMID: 19198835) Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9571-6. (PMID: 15980149) J Immunol. 2013 Jul 1;191(1):187-99. (PMID: 23733882) Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1969-74. (PMID: 14762166) Cancer Immunol Immunother. 2013 Mar;62(3):503-15. (PMID: 23001162) J Clin Invest. 2013 Oct;123(10 ):4479-88. (PMID: 24091329) Front Oncol. 2013 Apr 17;3:90. (PMID: 23616948) Cancer Gene Ther. 2014 Oct;21(10):441-7. (PMID: 25236493) |
| معلومات مُعتمدة: | T32 GM081061 United States GM NIGMS NIH HHS; I01 BX001619 United States BX BLRD VA; U01 AI124299 United States AI NIAID NIH HHS; R21 AI048785 United States AI NIAID NIH HHS; T32 CA090217 United States CA NCI NIH HHS; T32 AI055397 United States AI NIAID NIH HHS; R01 AI048785 United States AI NIAID NIH HHS; R21 AI118326 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Adoptive transfer; Cancer; Effector; Immunotherapy; Melanoma; Memory; T cell |
| تواريخ الأحداث: | Date Created: 20180531 Date Completed: 20191025 Latest Revision: 20191025 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5975512 |
| DOI: | 10.1186/s40425-018-0358-2 |
| PMID: | 29843822 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2051-1426 |
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| DOI: | 10.1186/s40425-018-0358-2 |