دورية أكاديمية
Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model.
العنوان: | Co-transfer of tumor-specific effector and memory CD8+ T cells enhances the efficacy of adoptive melanoma immunotherapy in a mouse model. |
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المؤلفون: | Contreras A; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, 2015 Linden Drive, Madison, WI, 53706, USA., Beems MV; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Tatar AJ; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Sen S; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Srinand P; Department of Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, Madison, WI, 53792, USA., Suresh M; Department of Pathobiological Sciences, University of Wisconsin School of Veterinary Medicine, 2015 Linden Drive, Madison, WI, 53706, USA., Luther TK; VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI, 48105, USA.; Department of Surgery, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA., Cho CS; VA Ann Arbor Healthcare System, 2215 Fuller Road, Ann Arbor, MI, 48105, USA. cliffcho@med.umich.edu.; Department of Surgery, University of Michigan Medical School, 1500 East Medical Center Drive, Ann Arbor, MI, 48109, USA. cliffcho@med.umich.edu. |
المصدر: | Journal for immunotherapy of cancer [J Immunother Cancer] 2018 May 29; Vol. 6 (1), pp. 41. Date of Electronic Publication: 2018 May 29. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: BMJ Publishing Group Ltd Country of Publication: England NLM ID: 101620585 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-1426 (Electronic) Linking ISSN: 20511426 NLM ISO Abbreviation: J Immunother Cancer Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2020- : London, United Kingdom : BMJ Publishing Group Ltd. Original Publication: London : BioMed Central, 2013- |
مواضيع طبية MeSH: | Adoptive Transfer/*methods , CD8-Positive T-Lymphocytes/*immunology , Immunologic Memory/*immunology , Immunotherapy/*methods , Melanoma/*immunology, Animals ; Disease Models, Animal ; Female ; Mice |
مستخلص: | Background: Adoptive cell transfer (ACT) is a promising cancer immunotherapeutic strategy that remains ineffective for a large subset of patients. ACT with memory CD8+ T cells (T Methods: Splenocytes harvested from Ly5.1+/C57BL/6 mice during and after infection with lymphocytic choriomeningitis virus (LCMV) were used to generate bona fide effector and memory CD8+ T cells specific for the LCMV epitope peptide GP33. Congenic Ly5.2+/C57BL/6 mice were inoculated with B16F10 melanoma cells transfected to express very low levels of GP33, then treated with ACT 7 days later with GP33-specific T Results: Inhibition of melanoma growth was strongest in mice receiving combinatorial ACT. Although combinatorial ACT and memory ACT resulted in maximal intratumoral infiltration of CD8+ T cells, combinatorial ACT induced stronger infiltration of endogenous CD8+ T cells than T Conclusions: These findings suggest that a novel combinatorial approach that takes advantage of the unique and complementary strengths of tumor-specific T |
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معلومات مُعتمدة: | T32 GM081061 United States GM NIGMS NIH HHS; I01 BX001619 United States BX BLRD VA; U01 AI124299 United States AI NIAID NIH HHS; R21 AI048785 United States AI NIAID NIH HHS; T32 CA090217 United States CA NCI NIH HHS; T32 AI055397 United States AI NIAID NIH HHS; R01 AI048785 United States AI NIAID NIH HHS; R21 AI118326 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Adoptive transfer; Cancer; Effector; Immunotherapy; Melanoma; Memory; T cell |
تواريخ الأحداث: | Date Created: 20180531 Date Completed: 20191025 Latest Revision: 20191025 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5975512 |
DOI: | 10.1186/s40425-018-0358-2 |
PMID: | 29843822 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2051-1426 |
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DOI: | 10.1186/s40425-018-0358-2 |