دورية أكاديمية
أعرض في EDS

Role of oxytocin in the ventral tegmental area in social reinforcement.

التفاصيل البيبلوغرافية
العنوان: Role of oxytocin in the ventral tegmental area in social reinforcement.
المؤلفون: Borland JM; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, USA., Grantham KN; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, USA., Aiani LM; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, USA., Frantz KJ; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, USA., Albers HE; Center for Behavioral Neuroscience, Neuroscience Institute, Georgia State University, Atlanta, GA, 30302, USA. Electronic address: biohea@gsu.edu.
المصدر: Psychoneuroendocrinology [Psychoneuroendocrinology] 2018 Sep; Vol. 95, pp. 128-137. Date of Electronic Publication: 2018 May 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7612148 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3360 (Electronic) Linking ISSN: 03064530 NLM ISO Abbreviation: Psychoneuroendocrinology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
مواضيع طبية MeSH: Reinforcement, Social*, Oxytocin/*physiology , Ventral Tegmental Area/*drug effects, Animals ; Conditioning, Operant ; Cricetinae ; Male ; Mesocricetus ; Oxytocin/metabolism ; Receptors, Oxytocin ; Reinforcement, Psychology ; Reward
مستخلص: The rewarding properties of social interactions play a critical role in the development and maintenance of social relationships, and deficits in social reward are associated with various psychiatric disorders. In the present study, we used a novel Operant Social Preference (OSP) task to investigate the reinforcing properties of social interactions under conditions of high or low reward value, and high or low behavioral effort in male Syrian hamsters. Further, we investigated the role of oxytocin (OT) in a key structure of the mesolimbic reward system, the ventral tegmental area (VTA), in mediating the reinforcing properties of social interaction. Adult male hamsters were placed in a three-chambered apparatus, and allowed access to either a social chamber containing an unrestrained conspecific or a non-social chamber, by pushing through a one-way entry, vertical-swing door. Increasing the duration of social interaction (reward value) decreased the frequency of entering the social interaction chambers, whereas decreasing the duration of social interaction conversely increased the frequency of entries. Moreover, increasing behavioral effort required to access social interaction decreased the frequency of entries, especially under conditions when the duration of social interaction was only 5 s. OT injected into the VTA decreased the frequency of entering social interaction chambers in a manner similar to that observed when duration was increased, whereas injection of an OT receptor antagonist in the VTA increased the frequency of seeking social interaction. Taken together, these data support the hypothesis that activation of OT receptors in the VTA are critical for the reinforcing properties of social interactions. Furthermore, social interactions may exhibit duration and cost dependent reinforcing effects on behavior similar to those observed with food and drugs of abuse.
(Copyright © 2018 Elsevier Ltd. All rights reserved.)
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معلومات مُعتمدة: F31 MH113367 United States MH NIMH NIH HHS; R01 MH110212 United States MH NIMH NIH HHS
فهرسة مساهمة: Keywords: Dopamine; Mesolimbic dopamine system; Neuropeptides; Operant; Social behavior; Social cognition; Social interaction; Social motivation; Social reward; Social salience; Vasopressin
المشرفين على المادة: 0 (Receptors, Oxytocin)
50-56-6 (Oxytocin)
تواريخ الأحداث: Date Created: 20180601 Date Completed: 20190410 Latest Revision: 20200306
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6109598
DOI: 10.1016/j.psyneuen.2018.05.028
PMID: 29852406
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-3360
DOI:10.1016/j.psyneuen.2018.05.028