دورية أكاديمية
Does renal function affect gadolinium deposition in the brain?
| العنوان: | Does renal function affect gadolinium deposition in the brain? |
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| المؤلفون: | Rahatli FK; Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. Electronic address: drkural@hotmail.com., Donmez FY; Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. Electronic address: fuldemyildirim@yahoo.com., Kibaroglu S; Baskent University, Faculty of Medicine, Department of Neurology, Ankara, Turkey. Electronic address: sedakibaroglu@gmail.com., Kesim C; Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. Electronic address: cagrikesim@hotmail.com., Haberal KM; Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. Electronic address: kmhbjk@hotmail.com., Turnaoglu H; Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. Electronic address: haletrn@yahoo.com., Agildere AM; Baskent University, Faculty of Medicine, Department of Radiology, Ankara, Turkey. Electronic address: muhtesema@gmail.com. |
| المصدر: | European journal of radiology [Eur J Radiol] 2018 Jul; Vol. 104, pp. 33-37. Date of Electronic Publication: 2018 Apr 20. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ireland Ltd Country of Publication: Ireland NLM ID: 8106411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7727 (Electronic) Linking ISSN: 0720048X NLM ISO Abbreviation: Eur J Radiol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Science Ireland Ltd Original Publication: Stuttgart ; New York : Thieme, [c1981- |
| مواضيع طبية MeSH: | Magnetic Resonance Imaging*/methods , Neuroimaging*, Cerebellar Nuclei/*diagnostic imaging , Contrast Media/*pharmacokinetics , Gadolinium DTPA/*pharmacokinetics , Globus Pallidus/*diagnostic imaging , Renal Insufficiency/*physiopathology , Thalamus/*diagnostic imaging, Adult ; Aged ; Cerebellar Nuclei/metabolism ; Contrast Media/administration & dosage ; Dose-Response Relationship, Radiation ; Female ; Gadolinium DTPA/administration & dosage ; Globus Pallidus/metabolism ; Humans ; Male ; Middle Aged ; Renal Dialysis ; Retrospective Studies ; Thalamus/metabolism ; Young Adult |
| مستخلص: | Objective: Was to compare T1 signal intensity ratios of dentate nucleus to cerebellar white matter (DN/cerebellum), dentate nucleus to pons (DN/pons) and globus pallidus to thalamus (GP/thalamus) in patients with normal renal function and in patients on chronic hemodialysis. To find out if renal function affects the deposition of gadolinium in brain after administration of linear gadolinium based contrast agents (GBCA). Methods: Seventy eight contrast enhanced brain MRIs (Magnetic Resonance Imaging) with linear GBCA of 13 patients on chronic hemodialysis and 13 patients with normal renal function retrospectively evaluated. The DN/pons, DN/cerebellum and GP/thalamus signal intensity ratios were measured from each brain MRI on unenhanced axial T1 weighted images. Results: In hemodialysis group statistically significant increase in the signal intensity ratios of DN/pons, DN/cerebellum and GP/thalamus were found between the first and the last brain MRIs (p = .001). The increase in the signal intensity ratios of DN/pons, DN/cerebellum and GP/thalamus between the first and the last brain MRIs in control group were not significant (p > 0.05). The signal intensity increase in DN and globus pallidus were significantly higher in hemodialysis group than control group (p < 0.05). Conclusions: Patients on hemodialysis had significantly higher DN and GP signal intensity increase compared to the patients with normal renal function. Renal function affects the rate of gadolinium deposition in the brain after administration of linear GBCA. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Brain MRI; Dentate nucleus; Gadolinium based contrast agent; Globus pallidus; Hemodialysis |
| المشرفين على المادة: | 0 (Contrast Media) K2I13DR72L (Gadolinium DTPA) |
| تواريخ الأحداث: | Date Created: 20180603 Date Completed: 20181219 Latest Revision: 20181219 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.ejrad.2018.04.017 |
| PMID: | 29857863 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-7727 |
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| DOI: | 10.1016/j.ejrad.2018.04.017 |