التفاصيل البيبلوغرافية
| العنوان: |
[Effects of chronic alcohol exposure on hippocampus and cerebral cortex neurons in mice]. |
| المؤلفون: |
Cui ZJ, Zhao KB, Deng JB |
| المصدر: |
Yao xue xue bao = Acta pharmaceutica Sinica [Yao Xue Xue Bao] 2016 Apr; Vol. 51 (4), pp. 573-9. |
| نوع المنشور: |
Journal Article |
| اللغة: |
Chinese |
| بيانات الدورية: |
Publisher: Zhongguo yao xue hui Country of Publication: China NLM ID: 21710340R Publication Model: Print Cited Medium: Print ISSN: 0513-4870 (Print) Linking ISSN: 05134870 NLM ISO Abbreviation: Yao Xue Xue Bao Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Beijing : Zhongguo yao xue hui |
| مواضيع طبية MeSH: |
Cerebral Cortex/*cytology , Ethanol/*adverse effects , Hippocampus/*cytology , Neurons/*drug effects, Alcohol Drinking/adverse effects ; Animals ; Central Nervous System ; Dendritic Spines ; Ethanol/administration & dosage ; Mice ; Synapses |
| مستخلص: |
This study was performed to investigate the changes of the number, morphology and ultrastructure of the central nervous system of mice during the long-term alcohol exposure. Mice at 60 days in age were used to establish the long-term alcohol exposure model. The structure of the central nervous system, such as nuclear antigen, dendritic spines and synapses, were labeled by the methods of immunocytochemistry and DiI (1,1’- dioctadecyl-3,3,3’,3’-tetramethy lindocarbocyanine perchlorate) scattering. The results showed that prolonged alcohol exposure could promote apoptosis of nerve cells in the central nervous system, and inhibit the proliferation of neural stem cells, which reduced the number of nerve cells in the central nervous system. Long-term ethanol exposure can also lead to a decrease in the density of dendritic spines of neuron, a smaller number of synapses(connections between nerve cells), and some changes in synaptic ultrastructure. The density of nerve cells and their dendritic spines, as well as the changes of synaptic ultrastructure, suggest that the function of nerve cells may be low. |
| المشرفين على المادة: |
3K9958V90M (Ethanol) |
| تواريخ الأحداث: |
Date Created: 20180604 Date Completed: 20180813 Latest Revision: 20181202 |
| رمز التحديث: |
20240628 |
| PMID: |
29859526 |
| قاعدة البيانات: |
MEDLINE |
