دورية أكاديمية
أعرض في EDS

Dose-response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current.

التفاصيل البيبلوغرافية
العنوان: Dose-response study for the highly aggressive and metastatic primary F3II mammary carcinoma under direct current.
المؤلفون: González MM; Departamento de Farmacia, Facultad de Ciencias Naturales y Exactas, Universidad de Oriente, Santiago de Cuba, Cuba., Morales DF; Centro Nacional para la Producción de Animales de Laboratorio, La Habana, Cuba., Cabrales LEB; Departamento de Investigación e Innovación, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba., Pérez DJ; Centro Nacional para la Producción de Animales de Laboratorio, La Habana, Cuba., Montijano JI; Instituto Universitario de Investigación de Matemáticas y Aplicaciones, Universidad de Zaragoza, Zaragoza, España., Castañeda ARS; Departamento de Telecomunicaciones, Facultad de Ingeniería Eléctrica, Universidad de Oriente, Santiago de Cuba, Cuba., González VGS; Grupo de las Industrias Biotecnológica y Farmacéuticas (BioCubaFarma), La Habana, Cuba., Posada OO; Centro Nacional para la Producción de Animales de Laboratorio, La Habana, Cuba., Martínez JA; Centro de Inmunología Molecular, La Habana, Cuba., Delgado AG; Centro de Inmunología Molecular, La Habana, Cuba., Martínez KG; Centro de Inmunología Molecular, La Habana, Cuba., Mon ML; Centro de Inmunología Molecular, La Habana, Cuba., Monzón KL; Centro de Inmunología Molecular, La Habana, Cuba., Ciria HMC; Departamento de Investigación e Innovación, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba., Beatón EO; Departamento de Ingeniería Biomédica, Facultad de Ingeniería Eléctrica, Universidad de Oriente, Santiago de Cuba, Cuba., Brooks SCA; Servicio de Medicina Interna, Hospital Provincial Saturnino Lora, Santiago de Cuba, Cuba., González TR; Dirección Municipal de Salud Pública, Servicio de Genética, Santiago de Cuba, Cuba., Jarque MV; Servicio de Oncohematología, Hospital Dr. Antonio Béguez César, Santiago de Cuba, Cuba., Mateus MAÓ; Servicio de Mastología, Hospital Oncológico Conrado Benítez, Santiago de Cuba, Cuba., Rodríguez JLG; Departamento de Investigación e Innovación, Centro Nacional de Electromagnetismo Aplicado, Universidad de Oriente, Santiago de Cuba, Cuba., Calzado EM; Departamento de Telecomunicaciones, Facultad de Ingeniería Eléctrica, Universidad de Oriente, Santiago de Cuba, Cuba.
المصدر: Bioelectromagnetics [Bioelectromagnetics] 2018 Sep; Vol. 39 (6), pp. 460-475. Date of Electronic Publication: 2018 Jun 05.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8008281 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-186X (Electronic) Linking ISSN: 01978462 NLM ISO Abbreviation: Bioelectromagnetics Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Wiley-Liss
Original Publication: New York, Liss.
مواضيع طبية MeSH: Electric Stimulation Therapy*/adverse effects , Electric Stimulation Therapy*/methods, Breast Neoplasms/*therapy , Carcinoma/*therapy, Animals ; Cell Line, Tumor ; Female ; Male ; Mice, Inbred BALB C ; Neoplasm Transplantation ; Random Allocation ; Survival Analysis ; Tumor Burden
مستخلص: Electrochemical treatment has been suggested as an effective alternative to local cancer therapy. Nevertheless, its effectiveness decreases when highly aggressive primary tumors are treated. The aim of this research was to understand the growth kinetics of the highly aggressive and metastatic primary F3II tumor growing in male and female BALB/c/Cenp mice under electrochemical treatment. Different amounts of electric charge (6, 9, and 18 C) were used. Two electrodes were inserted into the base, perpendicular to the tumor's long axis, keeping about 1 cm distance between them. Results have shown that the F3II tumor is highly sensitive to direct current. The overall effectiveness (complete response + partial response) of this physical agent was ≥75.0% and observed in 59.3% (16/27) of treated F3II tumors. Complete remission of treated tumors was observed in 22.2% (6/27). An unexpected result was the death of 11 direct current-treated animals (eight females and three males). It is concluded that direct current may be addressed to significantly affect highly aggressive and metastatic primary tumor growth kinetics, including the tumor complete response. Bioelectromagnetics. 39:460-475, 2018. © 2018 Wiley Periodicals, Inc.
(© 2018 Wiley Periodicals, Inc.)
فهرسة مساهمة: Keywords: direct current; electrochemical treatment; modified Gompertz equation; primary F3II mammary carcinoma
تواريخ الأحداث: Date Created: 20180606 Date Completed: 20181105 Latest Revision: 20181105
رمز التحديث: 20221213
DOI: 10.1002/bem.22132
PMID: 29870083
قاعدة البيانات: MEDLINE
الوصف
تدمد:1521-186X
DOI:10.1002/bem.22132