التفاصيل البيبلوغرافية
| العنوان: |
Dosimetric and microdosimetric analyses for blood exposed to reactor-derived thermal neutrons. |
| المؤلفون: |
Ali F; Radiobiology and Health Branch, Canadian Nuclear Laboratories, Chalk River, ON, K0J 1J0, Canada., Atanackovic J, Boyer C, Festarini A, Kildea J, Paterson LC, Rogge R, Stuart M, Richardson RB |
| المصدر: |
Journal of radiological protection : official journal of the Society for Radiological Protection [J Radiol Prot] 2018 Sep; Vol. 38 (3), pp. 1037-1052. Date of Electronic Publication: 2018 Jun 06. |
| نوع المنشور: |
Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: IOP Pub. Ltd Country of Publication: England NLM ID: 8809257 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1361-6498 (Electronic) Linking ISSN: 09524746 NLM ISO Abbreviation: J Radiol Prot Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: [Bristol, UK] : IOP Pub. Ltd., [c1988- |
| مواضيع طبية MeSH: |
Neutrons* , Nuclear Reactors* , Radiometry*, Blood/*radiation effects, Humans ; Lens, Crystalline/radiation effects ; Linear Energy Transfer ; Monte Carlo Method |
| مستخلص: |
Thermal neutrons are found in reactor, radiotherapy, aircraft, and space environments. The purpose of this study was to characterise the dosimetry and microdosimetry of thermal neutron exposures, using three simulation codes, as a precursor to quantitative radiobiological studies using blood samples. An irradiation line was designed employing a pyrolytic graphite crystal or-alternatively-a super mirror to expose blood samples to thermal neutrons from the National Research Universal reactor to determine radiobiological parameters. The crystal was used when assessing the relative biological effectiveness for dicentric chromosome aberrations, and other biomarkers, in lymphocytes over a low absorbed dose range of 1.2-14 mGy. Higher exposures using a super mirror will allow the additional quantification of mitochondrial responses. The physical size of the thermal neutron fields and their respective wavelength distribution was determined using the McStas Monte Carlo code. Spinning the blood samples produced a spatially uniform absorbed dose as determined from Monte Carlo N-Particle version 6 simulations. The major part (71%) of the total absorbed dose to blood was determined to be from the 14 N(n,p) 14 C reaction and the remainder from the 1 H(n,γ) 2 H reaction. Previous radiobiological experiments at Canadian Nuclear Laboratories involving thermal neutron irradiation of blood yielded a relative biological effectiveness of 26 ± 7. Using the Particle and Heavy Ion Transport Code System, a similar value of ∼19 for the quality factor of thermal neutrons initiating the 14 N(n,p) 14 C reaction in soft tissue was determined by microdosimetric simulations. This calculated quality factor is of similar high value to the experimentally-derived relative biological effectiveness, and indicates the potential of thermal neutrons to induce deleterious health effects in superficial organs such as cataracts of the eye lens. |
| تواريخ الأحداث: |
Date Created: 20180607 Date Completed: 20191111 Latest Revision: 20191111 |
| رمز التحديث: |
20231215 |
| DOI: |
10.1088/1361-6498/aaca9f |
| PMID: |
29871999 |
| قاعدة البيانات: |
MEDLINE |
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