دورية أكاديمية
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Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress.

التفاصيل البيبلوغرافية
العنوان: Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress.
المؤلفون: Bernardes N; Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.; Laboratory of Physiology and Metabolism, Cidade de Sao Paulo University (UNICID), São Paulo, SP, Brazil.; Hypertension Unit, Heart Institute (InCor), University of Sao Paulo (USP), São Paulo, SP, Brazil., da Silva Dias D; Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil., Stoyell-Conti FF; Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil., de Oliveira Brito-Monzani J; Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.; Federal University of Maranhao, São Luís, MA, Brazil., Malfitano C; Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil.; Department of Health Sciences, Federal University of Lavras (UFLA), Lavras, MG, Brazil., Caldini EG; Hypertension Unit, Heart Institute (InCor), University of Sao Paulo (USP), São Paulo, SP, Brazil., Ulloa L; Department of Surgery, Center of Immunology and Inflammation, Rutgers-New Jersey Medical School, Rutgers University, Newark, NJ, USA., Llesuy SF; Department of General and Inorganic Chemistry, University of Buenos Aires, Buenos Aires, BA, Argentina., Irigoyen MC; Hypertension Unit, Heart Institute (InCor), University of Sao Paulo (USP), São Paulo, SP, Brazil., De Angelis K; Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, SP, Brazil. prof.kangelis@yahoo.com.br.; Hypertension Unit, Heart Institute (InCor), University of Sao Paulo (USP), São Paulo, SP, Brazil. prof.kangelis@yahoo.com.br.; Departament of Physiology, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil. prof.kangelis@yahoo.com.br.
المصدر: Scientific reports [Sci Rep] 2018 Jun 05; Vol. 8 (1), pp. 8578. Date of Electronic Publication: 2018 Jun 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Disease Models, Animal*, Baroreflex/*physiology , Heart/*physiopathology , Metabolic Syndrome/*physiopathology , Myocardium/*metabolism, Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Baroreflex/drug effects ; Fructose/administration & dosage ; Fructose/pharmacology ; Heart/drug effects ; Hemodynamics/drug effects ; Hemodynamics/physiology ; Hypertension/metabolism ; Hypertension/physiopathology ; Inflammation/metabolism ; Inflammation/physiopathology ; Insulin Resistance ; Interleukin-6/metabolism ; Male ; Metabolic Syndrome/metabolism ; Oxidative Stress/physiology ; Rats, Inbred SHR ; Rats, Wistar ; Tumor Necrosis Factor-alpha/metabolism
مستخلص: This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.
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المشرفين على المادة: 0 (Interleukin-6)
0 (Tumor Necrosis Factor-alpha)
30237-26-4 (Fructose)
تواريخ الأحداث: Date Created: 20180607 Date Completed: 20191021 Latest Revision: 20191022
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5988715
DOI: 10.1038/s41598-018-26816-4
PMID: 29872081
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-26816-4