دورية أكاديمية
أعرض في EDS

Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus.

التفاصيل البيبلوغرافية
العنوان: Presence of microsatellite instability in esophageal squamous cell carcinoma associated with chagasic megaesophagus.
المؤلفون: Campanella NC; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Lacerda CF; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Department of Digestive Surgery, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Berardinelli GN; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Abrahão-Machado LF; Department of Pathology & Molecular Diagnostics, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Cruvinel-Carloni A; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., De Oliveira ATT; Department of Digestive Surgery, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Scapulatempo-Neto C; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Department of Pathology & Molecular Diagnostics, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Crema E; Department of Digestive Surgery & Pathology, Medical School, UFTM -Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil., Adad SJ; Department of Digestive Surgery & Pathology, Medical School, UFTM -Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil., Rodrigues MAM; Department of Gastroenterology Surgery & Pathology, Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil., Henry MACA; Department of Gastroenterology Surgery & Pathology, Medical School, UNESP - São Paulo State University, Botucatu, São Paulo, Brazil., Guimarães DP; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Department of Endoscopy, Barretos Cancer Hospital, Barretos, São Paulo, Brazil., Reis RM; Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, São Paulo, Brazil.; Life & Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal.; ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
المصدر: Biomarkers in medicine [Biomark Med] 2018 Jun; Vol. 12 (6), pp. 573-582. Date of Electronic Publication: 2018 Jun 06.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Future Medicine Country of Publication: England NLM ID: 101312535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-0371 (Electronic) Linking ISSN: 17520363 NLM ISO Abbreviation: Biomark Med Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Future Medicine
مواضيع طبية MeSH: Microsatellite Instability*, Chagas Disease/*complications , Esophageal Achalasia/*complications , Esophageal Neoplasms/*complications , Esophageal Neoplasms/*genetics , Esophageal Squamous Cell Carcinoma/*complications , Esophageal Squamous Cell Carcinoma/*genetics, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged
مستخلص: Aim: The molecular pathogenesis of esophageal squamous cell carcinoma (ESCC) has been increasingly studied, but there is no report on the role of MSI in ESCC development associated with chagasic megaesophagus (CM).Results/methodology: In four ESCC/CM (4/19) we found microsatellite instability (MSI) alterations (21.1%), being three MSI-L (15.8%) and one MSI-H (5.3%). Four out of 35 ESCC cases showed MSI-L (11.4%) and only one out of 26 CM cases presented MSI-L (3.9%). The MSI-H was observed in an ESCC/CM patient that presents lack of MSH6 immunostaining corroborating deficiency in MMR pathway. Interestingly, the MSI-H ESCC/CM case also presented a deletion the HSP110 poly(T)17 gene.
Discussion/conclusion: Taking together, we concluded that MSI is a rare event in esophageal squamous cell carcinoma, but can be associated with CM.
فهرسة مساهمة: Keywords: Chagas disease; HSP10; MSH6; chagasic megaesophagus; esophageal squamous cell carcinoma; microsatellite instability; mismatch repair
تواريخ الأحداث: Date Created: 20180607 Date Completed: 20190722 Latest Revision: 20220331
رمز التحديث: 20221213
DOI: 10.2217/bmm-2017-0329
PMID: 29873509
قاعدة البيانات: MEDLINE
الوصف
تدمد:1752-0371
DOI:10.2217/bmm-2017-0329