دورية أكاديمية
IL-2 production and response in vitro by the leukocytes of patients with acquired immune deficiency syndrome.
| العنوان: | IL-2 production and response in vitro by the leukocytes of patients with acquired immune deficiency syndrome. |
|---|---|
| المؤلفون: | Reuben JM, Hersh EM, Murray JL, Munn CG, Mehta SR, Mansell PW |
| المصدر: | Lymphokine research [Lymphokine Res] 1985 Spring; Vol. 4 (2), pp. 103-16. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8308208 Publication Model: Print Cited Medium: Print ISSN: 0277-6766 (Print) Linking ISSN: 02776766 NLM ISO Abbreviation: Lymphokine Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York Ny : Mary Ann Liebert Original Publication: New York, NY : M.A. Liebert, [c1982-c1990] |
| مواضيع طبية MeSH: | Acquired Immunodeficiency Syndrome/*immunology , Interleukin-2/*biosynthesis , T-Lymphocytes/*metabolism, Acquired Immunodeficiency Syndrome/metabolism ; Adult ; Antigens, Surface/analysis ; Cells, Cultured ; Humans ; Interleukin-2/pharmacology ; Lymphatic Diseases/immunology ; Lymphatic Diseases/metabolism ; Lymphocyte Activation/drug effects ; Male ; Phytohemagglutinins/pharmacology ; Receptors, Immunologic/deficiency ; Receptors, Interleukin-2 ; T-Lymphocytes/immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 7 |
| مستخلص: | In order to investigate the nature of the T cell defect associated with the acquired immune deficiency syndrome (AIDS) we studied the ability of peripheral blood mononuclear cells from 8 patients with Kaposi's sarcoma (KS), 2 with opportunistic infection (OI), 23 with AIDS-related symptoms complex (ARC) without KS or OI (ARC), and 29 heterosexual controls to produce interleukin II (IL-2) on phytohemagglutinin (PHA) stimulation and to respond to exogenously supplied IL-2. Patients with AIDS as well as those with ARC produced adequate levels of IL-2 in response to lectin stimulation when compared to controls (AIDS, 3.07 +/- 1.98 units; ARC, 3.03 +/- 1.89 units; controls, 3.75 +/- 1.52 units). However, the ability of these patients' cells to respond in vitro to exogenously supplied IL-2 as measured on short-term PHA-stimulated T cell blasts, was found to be severely impaired in patients with AIDS and ARC (AIDS, 22.4 +/- 6.0 X 10(-3) cpm; ARC, 20.1 +/- 4.2 X 10(-3) cpm; control, 41.4 +/- 4.2 X 10(-3) cpm). This impairment was associated with diminished expression of the IL-2 receptor on 7-day-old lectin-stimulated T cells from both patient groups (AIDS, 17.7 +/- 5.7; ARC, 36.8 +/- 4.4; control 71.8 +/- 1.7). These results should be considered when IL-2 is proposed as potential therapy in the treatment of AIDS. They also suggest that the nature of the AIDS defect is related to impaired hormone receptor expression. |
| معلومات مُعتمدة: | CA-34674 United States CA NCI NIH HHS; RR5511-22 United States RR NCRR NIH HHS |
| المشرفين على المادة: | 0 (Antigens, Surface) 0 (Interleukin-2) 0 (Phytohemagglutinins) 0 (Receptors, Immunologic) 0 (Receptors, Interleukin-2) 0 (Tumor Necrosis Factor Receptor Superfamily, Member 7) |
| تواريخ الأحداث: | Date Created: 19850101 Date Completed: 19850709 Latest Revision: 20171116 |
| رمز التحديث: | 20240627 |
| PMID: | 2987624 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0277-6766 |
|---|