دورية أكاديمية
أعرض في EDS

Evaluation of the effects of the larvicides temephos on reproductive performance, embryofetal development and DNA integrity of Swiss mice.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the effects of the larvicides temephos on reproductive performance, embryofetal development and DNA integrity of Swiss mice.
المؤلفون: Vani JM; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil; Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Faculdade de Medicina 'Dr. Hélio Mandetta' - FAMED, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil., de Carvalho Schweich L; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil; Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Faculdade de Medicina 'Dr. Hélio Mandetta' - FAMED, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil., de Oliveira KRW; Programa de Pós-graduação em Química - INQUI, Universidade Federal de Mato Grosso do Sul- UFMS, Campo Grande, MS, Brazil; Laboratório de Combustiveis - LABCOM, Instituto de Química - INQUI, Universidade Federal de Mato Grosso do Sul- UFMS, Campo Grande, MS, Brazil., Auharek SA; Faculdade de Medicina do Mucuri, Universidade Federal dos Vales do Jequitinhonha e do Mucuri - UFVJM, Teófilo Otoni, MG, Brazil., Cunha-Laura AL; Programa de Mestrado em Farmácia, Instituto de Biociências - INBIO, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil., Antoniolli-Silva ACMB; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil; Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Faculdade de Medicina 'Dr. Hélio Mandetta' - FAMED, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil., Nazario CED; Programa de Pós-graduação em Química - INQUI, Universidade Federal de Mato Grosso do Sul- UFMS, Campo Grande, MS, Brazil; Laboratório de Combustiveis - LABCOM, Instituto de Química - INQUI, Universidade Federal de Mato Grosso do Sul- UFMS, Campo Grande, MS, Brazil., Oliveira RJ; Centro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil; Programa de Pós-graduação em Saúde e Desenvolvimento na Região Centro-Oeste, Faculdade de Medicina 'Dr. Hélio Mandetta' - FAMED, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brazil; Programa de Pós-graduação em Genética e Biologia Molecular, Centro de Ciências Biológicas - CCB, Universidade Estadual de Londrina, Londrina, PR, Brazil. Electronic address: rodrigo.oliveira@ufms.br.
المصدر: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2018 Jun; Vol. 148, pp. 22-27. Date of Electronic Publication: 2018 Mar 26.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 1301573 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9939 (Electronic) Linking ISSN: 00483575 NLM ISO Abbreviation: Pestic Biochem Physiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York Ny : Academic Press
مواضيع طبية MeSH: Aedes/*drug effects , DNA/*drug effects , Embryonic Development/*drug effects , Fetus/*drug effects , Insecticides/*toxicity , Larva/*drug effects , Reproduction/*drug effects , Temefos/*toxicity, Abnormalities, Drug-Induced ; Aedes/growth & development ; Animals ; Body Weight/drug effects ; DNA Damage ; Dose-Response Relationship, Drug ; Female ; Insecticides/metabolism ; Mice ; Micronucleus Tests ; Mutagens/toxicity ; Organ Size/drug effects ; Placenta/metabolism ; Pregnancy ; Temefos/metabolism ; Teratogens/toxicity ; Uterus/drug effects
مستخلص: Temephos is considered the gold standard by the Ministry of Health for controlling the larvae of the mosquito Aedes aegypti. The present study evaluated the effects of Temephos larvicide on the reproductive performance, embryo-fetal development and DNA integrity of Swiss mice. This study used 30 pregnant female mice: 10 were controls treated with drinking water at a dosage of 0.1 mL/10 g (body weight - b.w., administered orally - a.o.), and 20 were treated with Temephos at doses of 0.0043 mg/kg and 0.043 mg/kg (b.w., a.o.) during the gestational period. Statistical analysis showed that Temephos did not alter the biometric or reproductive parameters. Comparing the weight of the fetus to the stage of pregnancy demonstrated that the 0.0043 mg/kg dosage increased the size of the fetuses. No external malformations were detected. However, the 0.043 mg/kg dosage induced changes in the sternum, with the main change being the center of the sternum, xiphoid processes and absence of the manubrium. The other skeletal and visceral alterations did not differ from the control group and are considered variants of normality. The analysis of head measurements showed an increase in the anterior/posterior measurements of the glabella, the external occipital protuberance and the biauricular plane. The circumference and area of the head did not present significant differences. The micronucleus test showed only a 0.043 mg/kg increase in 48 h. Thus, it is considered that Temephos has a low teratogenic and genotoxic risk.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Intoxication; Malformation; Mutagenesis; Organophosphate; Teratogenesis
المشرفين على المادة: 0 (Insecticides)
0 (Mutagens)
0 (Teratogens)
9007-49-2 (DNA)
ONP3ME32DL (Temefos)
تواريخ الأحداث: Date Created: 20180613 Date Completed: 20180905 Latest Revision: 20180905
رمز التحديث: 20221213
DOI: 10.1016/j.pestbp.2018.03.010
PMID: 29891373
قاعدة البيانات: MEDLINE
الوصف
تدمد:1095-9939
DOI:10.1016/j.pestbp.2018.03.010