دورية أكاديمية
أعرض في EDS

Differential antibacterial control by neutrophil subsets.

التفاصيل البيبلوغرافية
العنوان: Differential antibacterial control by neutrophil subsets.
المؤلفون: Leliefeld PHC; Department of Surgery.; Laboratory of Translational Immunology, and., Pillay J; Laboratory of Translational Immunology, and.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Vrisekoop N; Laboratory of Translational Immunology, and.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Heeres M; Department of Surgery.; Laboratory of Translational Immunology, and., Tak T; Laboratory of Translational Immunology, and.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Kox M; Department of Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Rooijakkers SHM; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands; and., Kuijpers TW; Emma Children's Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Pickkers P; Department of Intensive Care, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands., Leenen LPH; Department of Surgery.; Laboratory of Translational Immunology, and., Koenderman L; Laboratory of Translational Immunology, and.; Department of Respiratory Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
المصدر: Blood advances [Blood Adv] 2018 Jun 12; Vol. 2 (11), pp. 1344-1355.
نوع المنشور: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : American Society of Hematology, [2016]-
مواضيع طبية MeSH: Phagocytosis*, Methicillin-Resistant Staphylococcus aureus/*immunology , Neutrophils/*immunology , Phagosomes/*immunology , Reactive Oxygen Species/*immunology, Acute Disease ; Adolescent ; Child ; Child, Preschool ; Female ; GPI-Linked Proteins/immunology ; Humans ; Inflammation/immunology ; Inflammation/microbiology ; Inflammation/pathology ; L-Selectin/immunology ; Male ; Neutrophils/microbiology ; Neutrophils/pathology ; Phagosomes/microbiology ; Receptors, IgG/immunology
مستخلص: Neutrophils comprise a heterogeneous population of cells essential for bacterial eradication, and defects in neutrophil function are associated with increased susceptibility to infection. In this study, neutrophils from healthy controls were shown to prevent bacterial proliferation for at least 48 hours when cocultured with methicillin-resistant Staphylococcus aureus (MRSA) in tissue-like scaffolds by establishing a bacteriostatic environment inside their phagolysosome. This intracellular bacterial containment is independent of reactive oxygen species because neutrophils that lack a functional nicotinamide adenine dinucleotide phosphate-oxidase complex displayed no defect in intracellular bacterial containment, whereas killing of the pathogen was impaired. During acute inflammation, a subset of CD16 bright /CD62L dim hypersegmented neutrophils displayed normal phagocytosis associated with a remarkably poor capacity to contain bacteria intracellularly. Conversely, CD16 dim -banded neutrophils were the only neutrophil subset that adequately contained MRSA. These findings demonstrate a clear neutrophil heterogeneity in their antimicrobial capacity and the appearance of neutrophil subsets with a clear differentiation in functionality during acute inflammation. Furthermore, this study provides an evolutionary basis for the rapid release of banded neutrophils into the circulation during acute inflammation.
(© 2018 by The American Society of Hematology.)
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المشرفين على المادة: 0 (FCGR3B protein, human)
0 (GPI-Linked Proteins)
0 (Reactive Oxygen Species)
0 (Receptors, IgG)
126880-86-2 (L-Selectin)
تواريخ الأحداث: Date Created: 20180614 Date Completed: 20190305 Latest Revision: 20220330
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5998927
DOI: 10.1182/bloodadvances.2017015578
PMID: 29895625
قاعدة البيانات: MEDLINE
الوصف
تدمد:2473-9537
DOI:10.1182/bloodadvances.2017015578