دورية أكاديمية
Cellular Responses in Drosophila melanogaster Following Teratogen Exposure.
| العنوان: | Cellular Responses in Drosophila melanogaster Following Teratogen Exposure. |
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| المؤلفون: | Bianchini MC; Universidade Federal do Pampa, Uruguaiana, RS, Brazil., Portela JLR; Universidade Federal do Pampa, Uruguaiana, RS, Brazil., Puntel RL; Universidade Federal do Pampa, Uruguaiana, RS, Brazil., Ávila DS; Universidade Federal do Pampa, Uruguaiana, RS, Brazil. daianaavila@unipampa.edu.br. |
| المصدر: | Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2018; Vol. 1797, pp. 243-276. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Totowa, NJ : Humana Press Original Publication: Clifton, N.J. : Humana Press, |
| مواضيع طبية MeSH: | Embryonic Development* , Life Cycle Stages* , Reproduction*, Drosophila melanogaster/*embryology , Embryo, Nonmammalian/*pathology , Teratogens/*toxicity , Toxicity Tests/*methods, Animals ; Drosophila melanogaster/drug effects ; Embryo, Nonmammalian/drug effects ; Female ; Larva ; Male ; Pupa |
| مستخلص: | Studies focusing on the teratogenicity of a series of new chemicals that are produced in a daily basis represent an important focus in toxicological/pharmaceutical research, particularly due to the risks arising from occupational exposure of the subjects. However, the complex mating procedures, scheduling of treatments, requirements for trained personnel, and elevated costs of traditional teratological assays with mammals hamper this type of assessments. Accordingly, the use of Drosophila melanogaster as a model for teratological studies has received considerable attention. Here some general protocols about Drosophila exposure-at different stages of their life cycle-to any chemical with putative teratological activity are presented. Importantly, some details about D. melanogaster embryonic, larval, pupal, or adult endpoints, that can be used to assess teratogenicity using flies as a model organism, are presented. |
| فهرسة مساهمة: | Keywords: Adult fly; Drosophila melanogaster; Embryonic; Endpoints; Larvae; Methods; Pupa; Teratogenicity |
| المشرفين على المادة: | 0 (Teratogens) |
| تواريخ الأحداث: | Date Created: 20180614 Date Completed: 20190225 Latest Revision: 20190225 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/978-1-4939-7883-0_13 |
| PMID: | 29896697 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-6029 |
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| DOI: | 10.1007/978-1-4939-7883-0_13 |