دورية أكاديمية
Serum myoglobin, creatine kinase, and cell-free DNA in endurance sled dogs and sled dogs with clinical rhabdomyolysis.
| العنوان: | Serum myoglobin, creatine kinase, and cell-free DNA in endurance sled dogs and sled dogs with clinical rhabdomyolysis. |
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| المؤلفون: | Devall VC; Aspen Animal Hospital, Calgary, AB, Canada., Goggs R; The Department of Clinical Sciences Cornell, University College of Veterinary Medicine, Ithaca, NY, 14853., Hansen C; The Department of Biology and Wildlife Management, the University of Alaska, Fairbanks, AK, 99709., Frye CW; The Department of Clinical Sciences Cornell, University College of Veterinary Medicine, Ithaca, NY, 14853., Letendre JA; The Department of Clinical Sciences Cornell, University College of Veterinary Medicine, Ithaca, NY, 14853., Wakshlag JJ; The Department of Clinical Sciences Cornell, University College of Veterinary Medicine, Ithaca, NY, 14853. |
| المصدر: | Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) [J Vet Emerg Crit Care (San Antonio)] 2018 Jul; Vol. 28 (4), pp. 310-316. Date of Electronic Publication: 2018 Jun 13. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Country of Publication: United States NLM ID: 101152804 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4431 (Electronic) Linking ISSN: 14764431 NLM ISO Abbreviation: J Vet Emerg Crit Care (San Antonio) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005-> : Malden, MA : Blackwell Original Publication: San Antonio, TX : Veterinary Emergency & Critical Care Society, [2001]- |
| مواضيع طبية MeSH: | Physical Conditioning, Animal*, Cell-Free Nucleic Acids/*blood , Creatine Kinase/*blood , Dog Diseases/*blood , Myoglobin/*blood , Rhabdomyolysis/*veterinary, Animals ; Cohort Studies ; Dogs ; Rhabdomyolysis/blood |
| مستخلص: | Objective: To evaluate whether cell-free DNA (cfDNA) concentrations are increased in dogs with exertional rhabdomyolysis and whether concentrations are correlated with serum myoglobin concentration and creatine kinase activity. Design: Observational cohort study. Setting: Yukon Quest 1,000-mile International Sled Dog Race 2015. Animals: Twelve normal competitive sled dogs; 5 dogs with rhabdomyolysis. Interventions: None. Measurements and Main Results: Blood was collected from all confirmed cases of exertional rhabdomyolysis and compared to the winning team at the midrace point. Results indicate that median cfDNA did not increase, but decreased by the race finish (prerace = 314.2 ng/mL versus midrace = 283.7 ng/mL versus postrace = 249.5 ng/mL). There were no rises in median cfDNA in dogs with rhabdomyolysis (255 ng/mL) negating its potential utility as a measure of acute skeletal muscle compromise. In contrast, myoglobin concentration and creatine kinase activity at the midrace point for normal dogs were significantly lower than dogs with rhabdomyolysis. Values for myoglobin and creatine kinase were strongly positively correlated (R = 0.91). Conclusions: cfDNA is not a useful biomarker for exertional rhabdomyolysis in contrast to myoglobin and creatine kinase. Further evaluation of timing and clinical signs suggests that exertional rhabdomyolysis occurs early in endurance activities. Among the dogs with rhabdomyolysis, the dog that demonstrated clinical signs had the highest serum creatine kinase activity and myoglobin concentration. (© Veterinary Emergency and Critical Care Society 2018.) |
| فهرسة مساهمة: | Keywords: biomarker; exertional rhadbomyolysis; muscle injury |
| المشرفين على المادة: | 0 (Cell-Free Nucleic Acids) 0 (Myoglobin) EC 2.7.3.2 (Creatine Kinase) |
| تواريخ الأحداث: | Date Created: 20180614 Date Completed: 20181127 Latest Revision: 20181127 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/vec.12731 |
| PMID: | 29898248 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1476-4431 |
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| DOI: | 10.1111/vec.12731 |