دورية أكاديمية
Alkaloids from Tetrastigma hemsleyanum and Their Anti-Inflammatory Effects on LPS-Induced RAW264.7 Cells.
| العنوان: | Alkaloids from Tetrastigma hemsleyanum and Their Anti-Inflammatory Effects on LPS-Induced RAW264.7 Cells. |
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| المؤلفون: | Wang CY; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. wangcaiyiamy@163.com., Jang HJ; Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. water815@kribb.re.kr., Han YK; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. kkoo_@naver.com., Su XD; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. suxiangdongnicky@163.com., Lee SW; Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. lswdoc@kribb.re.kr., Rho MC; Immunoregulatory Material Research Center, Korea Research Institute of Bioscience and Biotechnology, 181 Ipsin-gil, Jeongeup-si, Jeonbuk 56212, Korea. rho-m@kribb.re.kr., Wang HS; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China. whengshan@163.com., Yang SY; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. syyang@cnu.ac.kr., Kim YH; College of Pharmacy, Chungnam National University, Daejeon 34134, Korea. yhk@cnu.ac.kr. |
| المصدر: | Molecules (Basel, Switzerland) [Molecules] 2018 Jun 14; Vol. 23 (6). Date of Electronic Publication: 2018 Jun 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, c1995- |
| مواضيع طبية MeSH: | Alkaloids/*pharmacology , Anti-Inflammatory Agents/*pharmacology , Lipopolysaccharides/*adverse effects , Macrophages/*metabolism , Vitaceae/*chemistry, Alkaloids/chemistry ; Animals ; Anti-Inflammatory Agents/chemistry ; Cytokines/metabolism ; MAP Kinase Signaling System/drug effects ; Macrophages/cytology ; Macrophages/drug effects ; Mice ; Molecular Structure ; Nitric Oxide/metabolism ; Phosphorylation/drug effects ; Plant Components, Aerial/chemistry ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; RAW 264.7 Cells |
| مستخلص: | Alkaloids 1 ⁻ 10 were isolated from the aerial parts of Tetrastigma hemsleyanum (APTH) and obtained from species of the genus Tetrastigma for the first time. The chemical structures of the isolated compounds were identified by NMR, UV, and MS analyses. Their anti-inflammatory activities were investigated by measuring nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophages. Among all the isolates, compounds 6 , 7 and 10 showed potent inhibitory activity against LPS-stimulated NO production in RAW264.7 cells (IC |
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| فهرسة مساهمة: | Keywords: NO production; Tetrastigma hemsleyanum; alkaloid; anti-inflammatory activity |
| المشرفين على المادة: | 0 (Alkaloids) 0 (Anti-Inflammatory Agents) 0 (Cytokines) 0 (Lipopolysaccharides) 0 (Plant Extracts) 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20180615 Date Completed: 20181029 Latest Revision: 20190725 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6099609 |
| DOI: | 10.3390/molecules23061445 |
| PMID: | 29899226 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1420-3049 |
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| DOI: | 10.3390/molecules23061445 |