دورية أكاديمية
أعرض في EDS

Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster .

التفاصيل البيبلوغرافية
العنوان: Regulators of Long-Term Memory Revealed by Mushroom Body-Specific Gene Expression Profiling in Drosophila melanogaster .
المؤلفون: Widmer YF; Department of Biology, University of Fribourg, CH-1700, Switzerland., Bilican A; Interfaculty Bioinformatics Unit, University of Bern, CH-3012, Switzerland., Bruggmann R; Interfaculty Bioinformatics Unit, University of Bern, CH-3012, Switzerland., Sprecher SG; Department of Biology, University of Fribourg, CH-1700, Switzerland simon.sprecher@unifr.ch.
المصدر: Genetics [Genetics] 2018 Aug; Vol. 209 (4), pp. 1167-1181. Date of Electronic Publication: 2018 Jun 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0374636 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1943-2631 (Electronic) Linking ISSN: 00166731 NLM ISO Abbreviation: Genetics Subsets: MEDLINE
أسماء مطبوعة: Publication: 2021- : [Oxford] : Oxford University Press
Original Publication: Austin, Tex. [etc.]
مواضيع طبية MeSH: Memory, Long-Term*, Drosophila Proteins/*genetics , Drosophila melanogaster/*growth & development , Enoyl-CoA Hydratase/*genetics , Gene Expression Profiling/*methods , Mushroom Bodies/*chemistry, Animals ; Animals, Genetically Modified/growth & development ; Behavior, Animal ; Drosophila melanogaster/genetics ; Gene Expression Regulation, Developmental ; Gene Knockdown Techniques ; Organ Specificity ; RNA Interference
مستخلص: Memory formation is achieved by genetically tightly controlled molecular pathways that result in a change of synaptic strength and synapse organization. While for short-term memory traces, rapidly acting biochemical pathways are in place, the formation of long-lasting memories requires changes in the transcriptional program of a cell. Although many genes involved in learning and memory formation have been identified, little is known about the genetic mechanisms required for changing the transcriptional program during different phases of long-term memory (LTM) formation. With Drosophila melanogaster as a model system, we profiled transcriptomic changes in the mushroom body-a memory center in the fly brain-at distinct time intervals during appetitive olfactory LTM formation using the targeted DamID technique. We describe the gene expression profiles during these phases and tested 33 selected candidate genes for deficits in LTM formation using RNAi knockdown. We identified 10 genes that enhance or decrease memory when knocked-down in the mushroom body. For vajk-1 and hacd1 -the two strongest hits-we gained further support for their crucial role in appetitive learning and forgetting. These findings show that profiling gene expression changes in specific cell-types harboring memory traces provides a powerful entry point to identify new genes involved in learning and memory. The presented transcriptomic data may further be used as resource to study genes acting at different memory phases.
(Copyright © 2018 by the Genetics Society of America.)
References: FEBS Lett. 2008 Jul 9;582(16):2435-40. (PMID: 18554506)
Nucleic Acids Res. 2008 Jan;36(Database issue):D149-53. (PMID: 18158296)
Science. 2000 Apr 28;288(5466):672-5. (PMID: 10784450)
Genetics. 2013 Oct;195(2):469-80. (PMID: 23852386)
J Neurosci. 2011 Sep 21;31(38):13420-30. (PMID: 21940435)
Annu Rev Neurosci. 1998;21:127-48. (PMID: 9530494)
Nat Methods. 2012 Mar 04;9(4):357-9. (PMID: 22388286)
Nature. 2012 Dec 20;492(7429):433-7. (PMID: 23103875)
Bioinformatics. 2015 Oct 15;31(20):3371-3. (PMID: 26112292)
J Neurosci. 2008 Mar 19;28(12):3103-13. (PMID: 18354013)
Nucleic Acids Res. 2017 Jan 4;45(D1):D331-D338. (PMID: 27899567)
Hum Mol Genet. 2005 Jun 1;14(11):1417-27. (PMID: 15829503)
J Genet Genomics. 2015 Apr 20;42(4):141-9. (PMID: 25953352)
Dev Cell. 2013 Jul 15;26(1):101-12. (PMID: 23792147)
Dev Neurobiol. 2011 Nov;71(11):1040-53. (PMID: 21793226)
Curr Biol. 2013 Sep 9;23(17):R752-63. (PMID: 24028959)
Nat Rev Neurosci. 2007 May;8(5):341-54. (PMID: 17453015)
Learn Mem. 2013 Apr 16;20(5):267-73. (PMID: 23592037)
Cell Rep. 2016 Feb 23;14(7):1698-1709. (PMID: 26876166)
J Lipid Res. 2015 Nov;56(11):2094-101. (PMID: 26353752)
Curr Biol. 2011 Oct 11;21(19):1647-53. (PMID: 21962716)
Genetics. 2015 Apr;199(4):1173-82. (PMID: 25644700)
J Biol Chem. 2012 Jun 15;287(25):21396-405. (PMID: 22544743)
Gene. 2000 Oct 3;256(1-2):237-43. (PMID: 11054553)
J Neurosci. 2013 Apr 17;33(16):7057-65. (PMID: 23595763)
Nature. 2001 May 24;411(6836):476-80. (PMID: 11373680)
Mol Cell Biol. 2004 Apr;24(7):2767-78. (PMID: 15024066)
Nat Protoc. 2016 Sep;11(9):1586-98. (PMID: 27490632)
PLoS One. 2011 Jan 27;6(1):e15890. (PMID: 21298037)
J Chromatogr B Biomed Sci Appl. 2001 Jun 5;757(1):119-25. (PMID: 11419736)
J Comp Physiol A. 1985 Sep;157(2):263-77. (PMID: 3939242)
FEBS Lett. 2010 Nov 5;584(21):4375-8. (PMID: 20951134)
Science. 2002 Nov 8;298(5596):1248-51. (PMID: 12424383)
Psychol Bull. 1984 Nov;96(3):518-59. (PMID: 6096908)
Bioinformatics. 2014 Aug 1;30(15):2114-20. (PMID: 24695404)
Nature. 1990 Jun 21;345(6277):718-21. (PMID: 2141668)
J Neurosci. 2002 Sep 15;22(18):8305-11. (PMID: 12223585)
Cell. 1994 Oct 7;79(1):35-47. (PMID: 7923375)
Curr Biol. 2007 Apr 3;17(7):649-54. (PMID: 17363253)
Mol Biol Cell. 2006 Nov;17(11):4736-47. (PMID: 16943325)
Neuroreport. 1992 Oct;3(10):869-72. (PMID: 1421090)
Learn Mem. 2014 Sep 15;21(10):519-26. (PMID: 25225297)
Nature. 2012 Aug 23;488(7412):512-6. (PMID: 22810589)
Genome Biol. 2010;11(8):R90. (PMID: 20799968)
Physiol Rev. 2009 Jan;89(1):121-45. (PMID: 19126756)
Cell. 2007 Aug 24;130(4):663-77. (PMID: 17719544)
Nat Neurosci. 2002 Apr;5(4):348-55. (PMID: 11889468)
J Neurosci. 2013 Mar 27;33(13):5821-33. (PMID: 23536094)
J Neurogenet. 2009;23(1-2):156-72. (PMID: 19140035)
J Biol Chem. 2008 Apr 25;283(17):11199-209. (PMID: 18272525)
Learn Mem. 1998 May-Jun;5(1-2):38-51. (PMID: 10454371)
Nat Commun. 2016 Nov 14;7:13471. (PMID: 27841260)
Curr Opin Neurobiol. 1996 Apr;6(2):264-8. (PMID: 8725970)
Genetics. 2015 Nov;201(3):843-52. (PMID: 26320097)
Genes Brain Behav. 2009 Jun;8(4):407-15. (PMID: 19220480)
Science. 1994 Feb 4;263(5147):692-5. (PMID: 8303280)
Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14200-5. (PMID: 22893682)
Genome Res. 2015 Mar;25(3):445-58. (PMID: 25589440)
J Neurogenet. 1985 Feb;2(1):1-30. (PMID: 4020527)
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15230-5. (PMID: 16210248)
Nat Biotechnol. 2000 Apr;18(4):424-8. (PMID: 10748524)
Development. 2013 Jun;140(11):2434-42. (PMID: 23637332)
Nature. 2000 Aug 17;406(6797):722-6. (PMID: 10963596)
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12456-61. (PMID: 23832785)
Elife. 2015 Mar 31;4:null. (PMID: 25824290)
Adv Exp Med Biol. 2012;970:153-71. (PMID: 22351055)
Curr Biol. 2009 Aug 25;19(16):1341-50. (PMID: 19646879)
Curr Biol. 2003 Feb 18;13(4):286-96. (PMID: 12593794)
J Neurochem. 2006 Mar;96(5):1227-41. (PMID: 16464240)
Insect Biochem Mol Biol. 2017 Aug;87:45-54. (PMID: 28633893)
Nature. 2007 Jul 12;448(7150):151-6. (PMID: 17625558)
Neurosci Res. 2005 Sep;53(1):34-8. (PMID: 15996778)
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):349-54. (PMID: 20018662)
Nat Commun. 2015 Jun 17;6:7279. (PMID: 26081261)
Neuron. 2007 Jan 18;53(2):261-77. (PMID: 17224407)
Brief Bioinform. 2011 Sep;12(5):449-62. (PMID: 21873635)
Nat Genet. 2000 May;25(1):25-9. (PMID: 10802651)
Learn Mem. 2009 Apr 29;16(5):332-7. (PMID: 19403796)
Science. 2009 Sep 4;325(5945):1258-61. (PMID: 19729657)
Dev Biol. 2010 Aug 15;344(2):772-83. (PMID: 20513443)
Cell. 2014 Mar 27;157(1):163-86. (PMID: 24679534)
Science. 2003 Dec 5;302(5651):1765-8. (PMID: 14657498)
Neurosci Lett. 1993 Apr 2;152(1-2):33-6. (PMID: 8100053)
فهرسة مساهمة: Keywords: Drosophila melanogaster; learning; long-term memory; targeted DamID; transcriptome
المشرفين على المادة: 0 (Drosophila Proteins)
0 (vajk-1protein, Drosophila)
EC 4.2.1.134 (Hacd1 protein, Drosophila)
EC 4.2.1.17 (Enoyl-CoA Hydratase)
تواريخ الأحداث: Date Created: 20180622 Date Completed: 20181009 Latest Revision: 20181114
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6063240
DOI: 10.1534/genetics.118.301106
PMID: 29925565
قاعدة البيانات: MEDLINE
الوصف
تدمد:1943-2631
DOI:10.1534/genetics.118.301106