دورية أكاديمية
Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory.
| العنوان: | Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory. |
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| المؤلفون: | Gould JM; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom.; Centre for Human Development, Stem Cells and Regeneration, University of Southampton, SO16 6YD Southampton, United Kingdom., Smith PJ; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom., Airey CJ; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom., Mort EJ; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Airey LE; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom., Warricker FDM; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom., Pearson-Farr JE; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Weston EC; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Gould PJW; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Semmence OG; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Restall KL; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom., Watts JA; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., McHugh PC; Centre for Biomarker Research, University of Huddersfield, HD1 3DH Huddersfield, United Kingdom., Smith SJ; Centre for Human Development, Stem Cells and Regeneration, University of Southampton, SO16 6YD Southampton, United Kingdom.; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Dewing JM; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom.; Centre for Human Development, Stem Cells and Regeneration, University of Southampton, SO16 6YD Southampton, United Kingdom., Fleming TP; Centre for Human Development, Stem Cells and Regeneration, University of Southampton, SO16 6YD Southampton, United Kingdom.; Biological Sciences, University of Southampton, SO16 6YD Southampton, United Kingdom., Willaime-Morawek S; Clinical Neurosciences and Psychiatry, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, SO16 6YD Southampton, United Kingdom; s.willaime-morawek@soton.ac.uk.; Centre for Human Development, Stem Cells and Regeneration, University of Southampton, SO16 6YD Southampton, United Kingdom. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 31; Vol. 115 (31), pp. E7398-E7407. Date of Electronic Publication: 2018 Jun 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Diet, Protein-Restricted* , Maternal Nutritional Physiological Phenomena* , Memory, Short-Term* , Neurogenesis*, Brain/*embryology , Neural Stem Cells/*pathology, Animals ; Apoptosis ; Brain/pathology ; Cell Differentiation ; Cell Proliferation ; Female ; Mice |
| مستخلص: | Maternal protein malnutrition throughout pregnancy and lactation compromises brain development in late gestation and after birth, affecting structural, biochemical, and pathway dynamics with lasting consequences for motor and cognitive function. However, the importance of nutrition during the preimplantation period for brain development is unknown. We have previously shown that maternal low-protein diet (LPD) confined to the preimplantation period (Emb-LPD) in mice, with normal nutrition thereafter, is sufficient to induce cardiometabolic and locomotory behavioral abnormalities in adult offspring. Here, using a range of in vivo and in vitro techniques, we report that Emb-LPD and sustained LPD reduce neural stem cell (NSC) and progenitor cell numbers at E12.5, E14.5, and E17.5 through suppressed proliferation rates in both ganglionic eminences and cortex of the fetal brain. Moreover, Emb-LPD causes remaining NSCs to up-regulate the neuronal differentiation rate beyond control levels, whereas in LPD, apoptosis increases to possibly temper neuron formation. Furthermore, Emb-LPD adult offspring maintain the increase in neuron proportion in the cortex, display increased cortex thickness, and exhibit short-term memory deficit analyzed by the novel-object recognition assay. Last, we identify altered expression of fragile X family genes as a potential molecular mechanism for adverse programming of brain development. Collectively, these data demonstrate that poor maternal nutrition from conception is sufficient to cause abnormal brain development and adult memory loss. Competing Interests: The authors declare no conflict of interest. |
| التعليقات: | Comment in: Proc Natl Acad Sci U S A. 2018 Jul 31;115(31):7852-7854. (PMID: 29976838) |
| References: | Biochim Biophys Acta. 2016 Jul;1859(7):906-13. (PMID: 27060415) Nat Neurosci. 2013 Sep;16(9):1228-1237. (PMID: 23912948) Brain Res Dev Brain Res. 2001 Dec 14;132(1):23-31. (PMID: 11744104) Neurosci Behav Physiol. 2008 Feb;38(2):139-43. (PMID: 18197379) J Biol Chem. 2001 Aug 10;276(32):30467-74. (PMID: 11399758) BMC Neurosci. 2006 Nov 15;7:77. (PMID: 17105671) Ann Hum Biol. 2009 Sep-Oct;36(5):445-58. (PMID: 19562567) PLoS One. 2013;8(1):e54707. (PMID: 23382945) Nutr Res. 2015 Jan;35(1):76-87. (PMID: 25433908) Reprod Fertil Dev. 2015 May;27(4):684-92. (PMID: 25730413) Clin Obstet Gynecol. 2013 Sep;56(3):511-9. (PMID: 23787713) Neurosci Biobehav Rev. 2012 Jul;36(6):1463-80. (PMID: 22487135) Physiol Behav. 2014 Apr 22;129:237-54. (PMID: 24607933) Br J Nutr. 2002 Oct;88(4):379-87. (PMID: 12323087) J Biol Chem. 2012 Aug 31;287(36):30842-52. (PMID: 22822062) Brain Res. 1984 Jun 11;303(1):163-70. (PMID: 6203619) Science. 1992 Mar 27;255(5052):1707-10. (PMID: 1553558) Development. 2014 Mar;141(5):1140-50. (PMID: 24504338) PLoS One. 2011;6(12):e28745. (PMID: 22194901) Hum Mol Genet. 2002 Mar 1;11(5):487-98. (PMID: 11875043) Brain Behav. 2017 Aug 25;7(10):e00800. (PMID: 29075560) PLoS One. 2012;7(12):e52791. (PMID: 23300778) Autism Res. 2017 Oct;10(10):1584-1596. (PMID: 28590057) Neuroscience. 2009 May 19;160(3):651-60. (PMID: 19272428) Nat Genet. 2014 May;46(5):516-21. (PMID: 24658003) Dev Growth Differ. 2008 Jun;50 Suppl 1:S97-103. (PMID: 18430159) Development. 1996 Apr;122(4):1165-74. (PMID: 8620843) Biol Reprod. 2008 Feb;78(2):299-306. (PMID: 17989357) Nat Neurosci. 2013 Sep;16(9):1238-47. (PMID: 23912945) Neuron. 1994 Nov;13(5):1071-82. (PMID: 7946346) Hum Mol Genet. 2006 Jun 15;15(12):1984-94. (PMID: 16675531) Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E270-7. (PMID: 19920218) Eur J Neurosci. 2013 Jun;37(12):1987-93. (PMID: 23773068) Nutrients. 2014 Oct 14;6(10):4200-17. (PMID: 25317634) DNA Repair (Amst). 2014 Jul;19:114-29. (PMID: 24856239) Arch Gen Psychiatry. 2001 Jan;58(1):48-52. (PMID: 11146757) Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5449-54. (PMID: 17372207) J Neurochem. 2013 Jun;125(6):869-84. (PMID: 23570577) Brain Res. 2007 May 7;1148:226-33. (PMID: 17368432) J Neurochem. 2004 Dec;91(5):1125-37. (PMID: 15569256) Genes Cells. 2011 Jul;16(7):778-90. (PMID: 21668588) Hum Reprod. 2015 Apr;30(4):917-24. (PMID: 25697730) Maturitas. 2011 Oct;70(2):141-5. (PMID: 21802226) |
| معلومات مُعتمدة: | BB/F007450/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/I001840/1 United Kingdom Biotechnology and Biological Sciences Research Council |
| فهرسة مساهمة: | Keywords: DOHaD; low-protein diet; maternal diet; neural stem cells; neurogenesis |
| تواريخ الأحداث: | Date Created: 20180627 Date Completed: 20180924 Latest Revision: 20220129 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6077736 |
| DOI: | 10.1073/pnas.1721876115 |
| PMID: | 29941596 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.1721876115 |