دورية أكاديمية
GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location.
| العنوان: | GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location. |
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| المؤلفون: | De Souza Albuquerque MS; Universidade Federal de Pernambuco. marioalbuquerque91@gmail.com., Da Silva-Filho AF, Ferraz Cordeiro M, Deodato de Souza MF, Quirino MWL, Amorim Lima LR, Da Rocha Pitta MG, Martins MR, De Melo Rêgo MJB |
| المصدر: | European journal of histochemistry : EJH [Eur J Histochem] 2018 Jun 14; Vol. 62 (2), pp. 2931. Date of Electronic Publication: 2018 Jun 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: PagePress Publications Country of Publication: Italy NLM ID: 9207930 Publication Model: Electronic Cited Medium: Internet ISSN: 2038-8306 (Electronic) Linking ISSN: 1121760X NLM ISO Abbreviation: Eur J Histochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2010- : Pavia : PagePress Publications Original Publication: Pavia : Luigi Ponzio, [1992- |
| مواضيع طبية MeSH: | Adenocarcinoma/*enzymology , Adenocarcinoma/*pathology , Immunohistochemistry/*methods , N-Acetylgalactosaminyltransferases/*metabolism , Stomach Neoplasms/*enzymology , Stomach Neoplasms/*pathology, Adenocarcinoma/surgery ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Gastrectomy ; Humans ; Male ; Middle Aged ; Prognosis ; Stomach Neoplasms/surgery ; Polypeptide N-acetylgalactosaminyltransferase |
| مستخلص: | Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer. |
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| فهرسة مساهمة: | Keywords: Gastric adenocarcinoma; clinical-pathological analyses; immunohistochemistry.; polypeptide N-acetylgalactosaminyltransferases |
| المشرفين على المادة: | EC 2.4.1.- (N-Acetylgalactosaminyltransferases) |
| تواريخ الأحداث: | Date Created: 20180627 Date Completed: 20181029 Latest Revision: 20231213 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6038116 |
| DOI: | 10.4081/ejh.2018.2931 |
| PMID: | 29943957 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2038-8306 |
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| DOI: | 10.4081/ejh.2018.2931 |