دورية أكاديمية
أعرض في EDS

Vedolizumab for Ulcerative Colitis: Treatment Outcomes from the VICTORY Consortium.

التفاصيل البيبلوغرافية
العنوان: Vedolizumab for Ulcerative Colitis: Treatment Outcomes from the VICTORY Consortium.
المؤلفون: Narula N; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani.; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Peerani F; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani.; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Meserve J; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Kochhar G; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Chaudrey K; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Hartke J; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Chilukuri P; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Koliani-Pace J; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Winters A; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Katta L; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Shmidt E; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Hirten R; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani.; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Faleck D; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Parikh MP; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Whitehead D; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Boland BS; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Singh S; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Sagi SV; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Fischer M; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Chang S; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Barocas M; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Luo M; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Lasch K; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Bohm M; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Lukin D; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Sultan K; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Swaminath A; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Hudesman D; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Gupta N; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Shen B; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Kane S; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Loftus EV; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Siegel CA; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Sands BE; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Colombel JF; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Sandborn WJ; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani., Dulai PS; Icahn School of Medicine at Mount Sinai, New York, NY, uSA. McMaster university Medical Centre, Hamilton, ON, Canada. university of Alberta, Edmonton, AB, Canada. University of California - San Diego, La Jolla, CA, uSA. Cleveland Clinic Foundation, Cleveland, OH, uSA. Mayo Clinic, Rochester, MN, uSA. indiana university, indianapolis, iN, uSA. Dartmouth-Hitchcock Medical Center, Lebanon, NH, uSA. North Shore university Hospital, Manhasset, NY, uSA. New York university, New York, NY, uSA. Takeda Pharmaceuticals uSA inc., Deerfield, iL, uSA. Montefiore Medical Center, New York, NY, uSA. Lenox Hill Hospital, New York, NY, uSA. University of Mississippi, Jackson, MS, uSA. These authors contributed equally: Neeraj Narula, Farhad Peerani.
المصدر: The American journal of gastroenterology [Am J Gastroenterol] 2018 Sep; Vol. 113 (9), pp. 1345. Date of Electronic Publication: 2018 Jun 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 0421030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1572-0241 (Electronic) Linking ISSN: 00029270 NLM ISO Abbreviation: Am J Gastroenterol Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019-> : [Philadelphia, PA] : Wolters Kluwer Health
Original Publication: New York, Elsevier Science, -2003.
مواضيع طبية MeSH: Antibodies, Monoclonal, Humanized/*therapeutic use , Colectomy/*statistics & numerical data , Colitis, Ulcerative/*therapy , Gastrointestinal Agents/*therapeutic use , Infections/*epidemiology, Adult ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/immunology ; Colitis, Ulcerative/pathology ; Colon/diagnostic imaging ; Colon/pathology ; Colon/surgery ; Colonoscopy ; Female ; Follow-Up Studies ; Glucocorticoids/therapeutic use ; Humans ; Infections/immunology ; Male ; Middle Aged ; Registries/statistics & numerical data ; Remission Induction/methods ; Retrospective Studies ; Severity of Illness Index ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/immunology
مستخلص: Objectives: We aimed to quantify the safety and effectiveness of vedolizumab (VDZ) when used for UC, and to identify predictors of response to treatment.
Methods: Retrospective review (May 2014-December 2016) of VICTORY Consortium data. Adults with follow-up after starting VDZ for clinically active UC were included. Primary effectiveness outcomes were cumulative rates of clinical remission (resolution of all UC-related symptoms) and endoscopic remission (Mayo endoscopic sub-score 0). Key secondary effectiveness outcomes included cumulative rates of corticosteroid-free remission and deep remission (clinical remission and endoscopic remission). Cox proportional hazard analyses were used to identify independent predictors of treatment effectiveness. Non-response imputation (NRI) sensitivity analyses were performed for effectiveness outcomes. Key safety outcomes were rates of serious infection, serious adverse events, and colectomy.
Results: We included 321 UC patients (71% prior TNFα antagonist exposure, median follow-up 10 months). The 12-month cumulative rates of clinical remission and endoscopic remission were 51% and 41%, respectively. Corresponding rates for corticosteroid-free remission and deep remission were 37% and 30%, respectively. Using NRI, 12-month rates were 20% (n = 64/321) for clinical remission, 17% (n = 35/203) for endoscopic remission, 15% (n = 30/195) for corticosteroid-free remission, and 14% (n = 28/203) for deep remission. A majority of the patients without adequate follow-up at 12 months who were deemed non-responders using NRI had already achieved clinical remission (n = 70) or a significant clinical response (n = 36) prior to 12 months. VDZ discontinuation prior to 12 months was observed in 91 patients, for lack of response (n = 56), need for surgery (n = 29), or adverse event (n = 6). On multivariable analyses, prior exposure to a TNFα antagonist was associated with a reduced probability of achieving clinical remission (HR 0.53, 95% CI 0.38-0.75) and endoscopic remission (HR 0.51, 95% CI 0.29-0.88). Serious adverse events and serious infections were reported in 6% and 4% of patients, respectively. Overall cumulative rates of colectomy over 12 months were 13%, with lower rates observed in patients naive to TNFα antagonist therapy (2%) than those who had been exposed to TNFα antagonists (19%).
Conclusion: In this large real-world cohort we observed that VDZ was well tolerated and effective in achieving key clinical outcomes.
التعليقات: Erratum in: Am J Gastroenterol. 2018 Dec;113(12):1912. (PMID: 30390030)
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معلومات مُعتمدة: K23 DK117058 United States DK NIDDK NIH HHS; KL2 TR001444 United States TR NCATS NIH HHS; T32 DK007202 United States DK NIDDK NIH HHS
المشرفين على المادة: 0 (Antibodies, Monoclonal, Humanized)
0 (Gastrointestinal Agents)
0 (Glucocorticoids)
0 (TNF protein, human)
0 (Tumor Necrosis Factor-alpha)
9RV78Q2002 (vedolizumab)
تواريخ الأحداث: Date Created: 20180628 Date Completed: 20190906 Latest Revision: 20220410
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6445254
DOI: 10.1038/s41395-018-0162-0
PMID: 29946178
قاعدة البيانات: MEDLINE
الوصف
تدمد:1572-0241
DOI:10.1038/s41395-018-0162-0