دورية أكاديمية
أعرض في EDS

Genetic counseling in an indigenous Filipino community with a high prevalence of A2ML1-related otitis media.

التفاصيل البيبلوغرافية
العنوان: Genetic counseling in an indigenous Filipino community with a high prevalence of A2ML1-related otitis media.
المؤلفون: la Paz EMC; University of the Philippines (UP) Manila - National Institutes of Health (NIH), Pedro Gil St., 1000, Manila, Philippines.; Section of Genetics, Department of Pediatrics, UP College of Medicine - Philippine General Hospital (PGH), Taft Ave., Ermita, 1000, Manila, Philippines., Pedro M; Philippine National Ear Institute, UP Manila - NIH, Manila, Philippines., Yarza TKL; Philippine National Ear Institute, UP Manila - NIH, Manila, Philippines.; Newborn Hearing Screening Reference Center, UP Manila-NIH, Manila, Philippines., Lagrana-Villagracia SM; Philippine National Ear Institute, UP Manila - NIH, Manila, Philippines., Amoranto AJP; Institute of Human Genetics, UP Manila - NIH, Manila, Philippines., Jover EJM; Institute of Human Genetics, UP Manila - NIH, Manila, Philippines., Domine MTB; Institute of Human Genetics, UP Manila - NIH, Manila, Philippines., Chiong CM; Philippine National Ear Institute, UP Manila - NIH, Manila, Philippines.; Newborn Hearing Screening Reference Center, UP Manila-NIH, Manila, Philippines.; Department of Otorhinolaryngology, UP College of Medicine - PGH, Manila, Philippines., Santos-Cortez RLP; Philippine National Ear Institute, UP Manila - NIH, Manila, Philippines. regie.santos-cortez@ucdenver.edu.; Department of Otolaryngology, University of Colorado School of Medicine, 12700 E. 19th Ave., Aurora, CO, 80045, USA. regie.santos-cortez@ucdenver.edu.; Center for Children's Surgery, Children's Hospital Colorado, 13623 E. 16th Ave., Aurora, CO, 80045, USA. regie.santos-cortez@ucdenver.edu.
المصدر: Journal of community genetics [J Community Genet] 2019 Jan; Vol. 10 (1), pp. 143-151. Date of Electronic Publication: 2018 Jun 15.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: Germany NLM ID: 101551501 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1868-310X (Print) Linking ISSN: 1868310X NLM ISO Abbreviation: J Community Genet Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Heidelberg : Springer
مستخلص: In this report, we describe the knowledge and beliefs on causes and management of otitis media of an indigenous Filipino community with a high prevalence of otitis media that is associated with an A2ML1 variant. Community lectures and individual genetic counseling were provided as intervention. Knowledge, beliefs, and health care-seeking behavior pertaining to otitis media were assessed pre- and post-genetic counseling. Twenty-five heads of households were interviewed. Beliefs regarding etiology of ear discharge varied widely, with swimming in the sea as the most commonly cited cause of ear discharge. During the post-counseling session, poor personal hygiene, dirty environment, and familial inheritance were mentioned as risk factors for otitis media or ear discharge. Knowledge about the genotypes for the A2ML1 variant and otitis media diagnoses within the household influenced beliefs on the role of hygiene and genetic susceptibility to otitis media and attitudes towards health care-seeking behavior. Genetic counseling was associated with variable improvement in knowledge on otitis media and in their understanding of genetic susceptibility to otitis media due to the A2ML1 variant. Language barriers, literacy level, cultural factors, and the complex nature of genetic information made genetic counseling in the particular population a challenge. Insights drawn from this experience recommend follow-up visits in the community.
References: JAMA. 1999 Dec 8;282(22):2125-30. (PMID: 10591333)
J Speech Lang Hear Res. 2000 Feb;43(1):100-20. (PMID: 10668655)
J Genet Couns. 2002 Jun;11(3):193-212. (PMID: 12735295)
Pediatrics. 2004 May;113(5):1451-65. (PMID: 15121972)
Med Decis Making. 2005 Jul-Aug;25(4):398-405. (PMID: 16061891)
J Genet Couns. 2006 Apr;15(2):77-83. (PMID: 16761103)
Lancet Infect Dis. 2006 Oct;6(10):653-63. (PMID: 17008174)
EMBO J. 2007 Feb 21;26(4):915-22. (PMID: 17255931)
Patient Educ Couns. 2008 Dec;73(3):448-55. (PMID: 18755566)
EMBO Rep. 2008 Oct;9(10):943-7. (PMID: 18772895)
Acta Trop. 2009 Nov;112 Suppl 1:S21-31. (PMID: 19665983)
Pediatr Infect Dis J. 2011 Feb;30(2):95-9. (PMID: 20711085)
Laryngoscope. 2012 Mar;122(3):665-75. (PMID: 22252840)
PLoS One. 2012;7(4):e36226. (PMID: 22558393)
J Genet Couns. 2013 Dec;22(6):865-8. (PMID: 23553668)
Laryngoscope. 2014 May;124(5):1229-35. (PMID: 23929584)
Annu Rev Genomics Hum Genet. 2013;14:491-513. (PMID: 24003856)
J Genet Couns. 2013 Dec;22(6):917-24. (PMID: 24048708)
Infect Drug Resist. 2014 Jan 10;7:15-24. (PMID: 24453496)
J Community Genet. 2014 Oct;5(4):399-407. (PMID: 25026992)
Nat Genet. 2015 Aug;47(8):917-20. (PMID: 26121085)
J Genet Couns. 1997 Sep;6(3):269-86. (PMID: 26142235)
Otolaryngol Head Neck Surg. 2016 Feb;154(1 Suppl):S1-S41. (PMID: 26832942)
Pediatrics. 2016 Apr;137(4):. (PMID: 27020793)
Cochrane Database Syst Rev. 2016 Jun 12;(6):CD009163. (PMID: 27290722)
Otolaryngol Head Neck Surg. 2016 Nov;155(5):856-862. (PMID: 27484237)
Infect Dis Poverty. 2016 Nov 1;5(1):97. (PMID: 27799062)
معلومات مُعتمدة: R01 DC015004 United States DC NIDCD NIH HHS; Balik-Scientist Philippine Council for Health Research and Development - Department of Science and Technology; R01 DC015004 National Institute on Deafness and Other Communication Disorders
فهرسة مساهمة: Keywords: A2ML1; Filipino; Genetic counseling; Indigenous community; Otitis media
تواريخ الأحداث: Date Created: 20180628 Latest Revision: 20200929
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6325045
DOI: 10.1007/s12687-018-0368-2
PMID: 29949068
قاعدة البيانات: MEDLINE
الوصف
تدمد:1868-310X
DOI:10.1007/s12687-018-0368-2