دورية أكاديمية
أعرض في EDS

Endospore forming bacteria may be associated with maintenance of surgically-induced remission in Crohn's disease.

التفاصيل البيبلوغرافية
العنوان: Endospore forming bacteria may be associated with maintenance of surgically-induced remission in Crohn's disease.
المؤلفون: Laffin MR; Department of Surgery, University of Alberta, Edmonton, Alberta, Canada., Perry T; Department of Surgery, University of Alberta, Edmonton, Alberta, Canada., Park H; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Gillevet P; Microbiome Analysis Center, George Mason University, Manassas, Virginia, USA., Sikaroodi M; Microbiome Analysis Center, George Mason University, Manassas, Virginia, USA., Kaplan GG; Department of Medicine and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada., Fedorak RN; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Kroeker K; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Dieleman LA; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada., Dicken B; Department of Surgery, University of Alberta, Edmonton, Alberta, Canada., Madsen KL; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. karen.madsen@ualberta.ca.
المصدر: Scientific reports [Sci Rep] 2018 Jun 27; Vol. 8 (1), pp. 9734. Date of Electronic Publication: 2018 Jun 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Crohn Disease/*microbiology , Crohn Disease/*pathology , Endospore-Forming Bacteria/*physiology, Endospore-Forming Bacteria/genetics ; Female ; Firmicutes/genetics ; Firmicutes/isolation & purification ; Gastrointestinal Microbiome/genetics ; Gastrointestinal Microbiome/physiology ; Humans ; Ileum/surgery ; Least-Squares Analysis ; Male ; Middle Aged ; RNA, Ribosomal, 16S/genetics ; Remission Induction
مستخلص: Crohn's disease (CD) patients who undergo ileocolonic resection (ICR) typically have disease recurrence at the anastomosis which has been linked with a gut dysbiosis. The aims of this study were to define the mucosa-associated microbiota at the time of ICR and to determine if microbial community structure at the time of surgery was predictive of future disease relapse. Ileal biopsies were obtained at surgery and after 6 months from CD subjects undergoing ICR. Composition and function of mucosal-associated microbiota was assessed by 16S rRNA sequencing and PICRUSt analysis. Endoscopic recurrence was assessed using the Rutgeerts score. Analysis of mucosal biopsies taken at the time of surgery showed that decreased Clostridiales together with increased Enterobacteriales predicted disease recurrence. An increase in the endospore-forming Lachnospiraceae from surgery to 6 months post-ICR was associated with remission. A ratio of 3:1 between anaerobic endospore-forming bacterial families and aerobic families within the Firmicutes phylum was predictive of maintenance of remission. Gut recolonization following ICR is facilitated by microbes which are capable of either aerobic respiration or endospore formation. The relative proportions of these species at the time of surgery may be predictive of subsequent microbial community restoration and disease recurrence.
References: Genome Biol. 2011 Jun 24;12(6):R60. (PMID: 21702898)
Microbiome. 2014 Jul 21;2:25. (PMID: 25061514)
J Crohns Colitis. 2017 Feb;11(2):191-203. (PMID: 27466174)
Can J Gastroenterol. 2005 Sep;19 Suppl A:5A-36A. (PMID: 16151544)
Nucleic Acids Res. 2016 Jan 4;44(D1):D471-80. (PMID: 26527732)
Adv Immunol. 2014;121:91-119. (PMID: 24388214)
Surg Infect (Larchmt). 2007 Dec;8(6):557-66. (PMID: 18171114)
Gastroenterology. 2013 Nov;145(5):996-1006. (PMID: 23896172)
Proc Natl Acad Sci U S A. 1985 Oct;82(20):6955-9. (PMID: 2413450)
Inflamm Bowel Dis. 2015 Jul;21(7):1479-90. (PMID: 26070001)
Gastroenterology. 2004 Aug;127(2):412-21. (PMID: 15300573)
Gut. 1984 Jun;25(6):665-72. (PMID: 6735250)
Science. 2011 Jan 21;331(6015):337-41. (PMID: 21205640)
Am J Gastroenterol. 2002 Apr;97(4):939-46. (PMID: 12003430)
BMC Gastroenterol. 2013 Aug 22;13:131. (PMID: 23964800)
Am J Surg. 2016 Aug;212(2):345-51. (PMID: 27182048)
PLoS One. 2013 Aug 27;8(8):e73140. (PMID: 24015295)
Nat Biotechnol. 2013 Sep;31(9):814-21. (PMID: 23975157)
EMBO Rep. 2013 Apr;14(4):319-27. (PMID: 23478337)
Nat Rev Gastroenterol Hepatol. 2017 Jan;14(1):43-54. (PMID: 27729657)
Lancet. 1991 Sep 28;338(8770):771-4. (PMID: 1681159)
Gut. 2016 Jun;65(6):954-62. (PMID: 26628508)
Ann Surg. 2016 Jul;264(1):73-80. (PMID: 27275778)
Science. 2013 Feb 8;339(6120):708-11. (PMID: 23393266)
J Gastroenterol Hepatol. 2015 Feb;30(2):268-78. (PMID: 25087692)
Nature. 2016 May 04;533(7604):543-546. (PMID: 27144353)
J Infect Dis. 2016 Jul 15;214(2):173-81. (PMID: 26908752)
N Engl J Med. 2009 Nov 19;361(21):2066-78. (PMID: 19923578)
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6. (PMID: 18936492)
Int J Syst Evol Microbiol. 2002 Nov;52(Pt 6):2141-6. (PMID: 12508881)
المشرفين على المادة: 0 (RNA, Ribosomal, 16S)
تواريخ الأحداث: Date Created: 20180629 Date Completed: 20191010 Latest Revision: 20191010
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6021420
DOI: 10.1038/s41598-018-28071-z
PMID: 29950676
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-018-28071-z