دورية أكاديمية
LONG TERM OUTCOMES OF AUGMENTED TRABECULECTOMY WITH 5-FLUOROURACIL IN NIGERIA.
| العنوان: | LONG TERM OUTCOMES OF AUGMENTED TRABECULECTOMY WITH 5-FLUOROURACIL IN NIGERIA. |
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| المؤلفون: | Olawoye OO; Department of Ophthalmology, College of Medicine University of Ibadan, Ibadan, Nigeria., Ashaye AO; Department of Ophthalmology, College of Medicine University of Ibadan, Ibadan, Nigeria. |
| المصدر: | Journal of the West African College of Surgeons [J West Afr Coll Surg] 2017 Jan-Mar; Vol. 7 (1), pp. 92-112. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wolters Kluwer - Medknow Country of Publication: India NLM ID: 101597958 Publication Model: Print Cited Medium: Print ISSN: 2276-6944 (Print) Linking ISSN: 22766944 NLM ISO Abbreviation: J West Afr Coll Surg Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: [Mumbai] : Wolters Kluwer - Medknow Original Publication: Lagos : The West African College of Surgeons, [2011]- |
| مستخلص: | Background: Glaucoma in sub-Saharan Africa has been described as a surgical disease because of the high cost of medical treatment, poor compliance and unavailability of medications. Aim: This study reports the long-term outcomes and complication rates following trabeculectomy with 5-fluorouracil in a case series of Nigerians. Design of Study: This was a retrospective, observational, non-comparative case series. Setting: University College Hospital, Ibadan, Nigeria. Methodology: Each patient had complete ophthalmic evaluation. The post-operative intraocular pressure (IOP), visual acuity outcomes and post operative complications were assessed. The World Glaucoma Association consensus on surgical outcome was used to evaluate surgical outcome. Results: Of the 292 patients who presented with glaucoma during this period, a total of 47 eyes of 31 patients (10.6%) had trabeculectomy with 5-FU. The mean presenting intraocular pressure (IOP) was 31.8±12.2mmHg. At three years post-operatively, 48.5% achieved complete success without medications while 90.9% achieved success with or without medications at an IOP cut off of ≤21mmHg. At the same time point of 3 years and an IOP cut off of ≤15mmHg, 63.6% achieved success with or without medications. At a mean post-operative period of 43± 19.6 months, (range 12-86 months), mean IOP had reduced from a preoperative mean of 31.8±12.2mmHg to 15.4±4.7mmHg (P<0.001). Conclusion: Trabeculectomy with 5-Fluorouracil is effective in the long term in reducing IOP with minimal complications in this population of Nigerians. Competing Interests: Competing Interests: The authors have declared that no competing interests exist. |
| References: | Arch Ophthalmol. 1991 Aug;109(8):1090-5. (PMID: 1867550) Ophthalmology. 2000 Dec;107(12):2305-9. (PMID: 11097613) JAMA Ophthalmol. 2013 May;131(5):651-8. (PMID: 23538512) Ophthalmic Surg Lasers. 2000 Jan-Feb;31(1):24-30. (PMID: 10976557) Ophthalmology. 1996 Nov;103(11):1925-33. (PMID: 8942891) Eye (Lond). 2001 Jun;15(Pt 3):274-8. (PMID: 11450719) Middle East Afr J Ophthalmol. 2012 Jan;19(1):147-52. (PMID: 22346131) Br J Ophthalmol. 1994 Jun;78(6):466-75. (PMID: 8060931) Br J Ophthalmol. 2000 Aug;84(8):860-4. (PMID: 10906092) Am J Ophthalmol. 2002 Oct;134(4):521-8. (PMID: 12383808) BMJ. 2006 Nov 4;333(7575):942. (PMID: 17023435) Clin Exp Ophthalmol. 2004 Feb;32(1):23-8. (PMID: 14746586) Arch Ophthalmol. 2001 Dec;119(12):1771-9. (PMID: 11735786) Ophthalmology. 2009 Feb;116(2):175-84. (PMID: 19187822) Ophthalmology. 1995 Sep;102(9):1263-9. (PMID: 9097762) J Ophthalmic Vis Res. 2013 Apr;8(2):126-33. (PMID: 23943687) Ophthalmology. 1989 Sep;96(9):1363-8. (PMID: 2789357) Ghana Med J. 2007 Dec;41(4):176-80. (PMID: 18464899) Arch Ophthalmol. 1997 Aug;115(8):1051-7. (PMID: 9258228) Ophthalmology. 1998 Jul;105(7):1146-64. (PMID: 9663215) Am J Ophthalmol. 2000 Oct;130(4):429-40. (PMID: 11024415) Clin Exp Ophthalmol. 2012 May-Jun;40(4):e176-82. (PMID: 21718411) Am J Ophthalmol. 2001 Sep;132(3):311-20. (PMID: 11530042) Eye (Lond). 2004 May;18(5):491-7. (PMID: 15131680) Eye (Lond). 2009 Feb;23(2):448-52. (PMID: 17932507) J Glaucoma. 2008 Oct-Nov;17(7):578-83. (PMID: 18854737) Am J Ophthalmol. 1993 Jul 15;116(1):72-8. (PMID: 8328546) J Glaucoma. 1998 Apr;7(2):82-5. (PMID: 9559492) Ophthalmology. 2001 Nov;108(11):1943-53. (PMID: 11713061) Glob Health Action. 2016 Dec 06;9:31886. (PMID: 27924740) Ophthalmology. 1998 Jul;105(7):1137-45. (PMID: 9663214) |
| فهرسة مساهمة: | Keywords: Nigerians; Surgical Outcome; Trabeculectomy |
| تواريخ الأحداث: | Date Created: 20180629 Latest Revision: 20220318 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6018030 |
| PMID: | 29951457 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2276-6944 |
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