دورية أكاديمية
Minor zygotic gene activation is essential for mouse preimplantation development.
| العنوان: | Minor zygotic gene activation is essential for mouse preimplantation development. |
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| المؤلفون: | Abe KI; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 277-8562 Kashiwa, Japan., Funaya S; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 277-8562 Kashiwa, Japan., Tsukioka D; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 277-8562 Kashiwa, Japan., Kawamura M; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 277-8562 Kashiwa, Japan., Suzuki Y; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, 277-0882 Kashiwa, Japan., Suzuki MG; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 277-8562 Kashiwa, Japan., Schultz RM; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104; rschultz@sas.upenn.edu aokif@k.u-tokyo.ac.jp.; Department of Anatomy, Physiology, and Cell Biology, School of Veterinary Medicine, University of California, Davis, CA 95616., Aoki F; Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, 277-8562 Kashiwa, Japan; rschultz@sas.upenn.edu aokif@k.u-tokyo.ac.jp. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Jul 17; Vol. 115 (29), pp. E6780-E6788. Date of Electronic Publication: 2018 Jul 02. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Blastocyst/*metabolism , Embryonic Development/*physiology , Gene Expression Regulation, Developmental/*physiology , Zygote/*metabolism, Animals ; Blastocyst/cytology ; Dichlororibofuranosylbenzimidazole/pharmacology ; Embryonic Development/drug effects ; Gene Expression Regulation, Developmental/drug effects ; Histones/metabolism ; Mice ; Zygote/cytology |
| مستخلص: | In mice, transcription initiates at the mid-one-cell stage and transcriptional activity dramatically increases during the two-cell stage, a process called zygotic gene activation (ZGA). Associated with ZGA is a marked change in the pattern of gene expression that occurs after the second round of DNA replication. To distinguish ZGA before and after the second-round DNA replication, the former and latter are called minor and major ZGA, respectively. Although major ZGA are required for development beyond the two-cell stage, the function of minor ZGA is not well understood. Transiently inhibiting minor ZGA with 5, 6-dichloro-1-β-d-ribofuranosyl-benzimidazole (DRB) resulted in the majority of embryos arresting at the two-cell stage and retention of the H3K4me3 mark that normally decreases. After release from DRB, at which time major ZGA normally occurred, transcription initiated with characteristics of minor ZGA but not major ZGA, although degradation of maternal mRNA normally occurred. Thus, ZGA occurs sequentially starting with minor ZGA that is critical for the maternal-to-zygotic transition. Competing Interests: The authors declare no conflict of interest. |
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| معلومات مُعتمدة: | R01 HD022681 United States HD NICHD NIH HHS; R37 HD022681 United States HD NICHD NIH HHS |
| فهرسة مساهمة: | Keywords: gene expression; maternal-to-zygotic transition; minor zygotic gene activation; preimplantation mouse embryo |
| المشرفين على المادة: | 0 (Histones) 53-85-0 (Dichlororibofuranosylbenzimidazole) |
| تواريخ الأحداث: | Date Created: 20180704 Date Completed: 20180918 Latest Revision: 20240718 |
| رمز التحديث: | 20240718 |
| مُعرف محوري في PubMed: | PMC6055165 |
| DOI: | 10.1073/pnas.1804309115 |
| PMID: | 29967139 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
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| DOI: | 10.1073/pnas.1804309115 |