دورية أكاديمية
Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model.
| العنوان: | Comparative enhancement of curcumin cytotoxic photodynamic activity by nanoliposomes and gold nanoparticles with pharmacological appraisal in HepG2 cancer cells and Erlich solid tumor model. |
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| المؤلفون: | Fadel M; a Pharmaceutical Technology Unit, Department of Medical Applications of Laser , National Institute of Laser Enhanced Sciences, Cairo University , Cairo , Egypt., Kassab K; b Photobiology and Cell Photosensitization Lab , National Institute of Laser Enhanced Sciences, Cairo University , Cairo , Egypt., Abd El Fadeel DA; a Pharmaceutical Technology Unit, Department of Medical Applications of Laser , National Institute of Laser Enhanced Sciences, Cairo University , Cairo , Egypt., Nasr M; c Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy , Mutah University , Jordan.; d Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy , Ain Shams University , Cairo , Egypt., El Ghoubary NM; a Pharmaceutical Technology Unit, Department of Medical Applications of Laser , National Institute of Laser Enhanced Sciences, Cairo University , Cairo , Egypt. |
| المصدر: | Drug development and industrial pharmacy [Drug Dev Ind Pharm] 2018 Nov; Vol. 44 (11), pp. 1809-1816. Date of Electronic Publication: 2018 Sep 05. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 7802620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5762 (Electronic) Linking ISSN: 03639045 NLM ISO Abbreviation: Drug Dev Ind Pharm Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: New York, Dekker. |
| مواضيع طبية MeSH: | Nanoparticles*, Antineoplastic Agents/*administration & dosage , Carcinoma, Ehrlich Tumor/*drug therapy , Curcumin/*administration & dosage , Photochemotherapy/*methods, Animals ; Carcinoma, Ehrlich Tumor/pathology ; Curcumin/chemistry ; Curcumin/pharmacology ; Drug Liberation ; Hep G2 Cells ; Humans ; Liposomes ; Male ; Metal Nanoparticles ; Mice ; Particle Size ; Spectroscopy, Fourier Transform Infrared |
| مستخلص: | Curcumin is a natural pigment that generates singlet oxygen upon light excitation, hence it can be used as a photosensitizer in photodynamic therapy. The extremely low water solubility and poor systemic bioavailability make curcumin a challenging molecule to be used clinically. In this study, two nanocarrier systems for curcumin were prepared and characterized; nanoliposomes and polyvinyl pyrrolidone-capped gold nanoparticles. The dark and photocytotoxicity were investigated as a function of light fluence rate (100 and 200 mW/cm 2 ) on HepG2 cancer cells. In vivo Erlich tumor model was developed and comparison of the tumor volume, survival rate, and histopathological alterations was made for the two nanocarriers. Results showed that both curcumin nanocarriers were successfully prepared and characterized. Light irradiation was able to augment the cytotoxicity of both curcumin liposomes and gold nanoparticles, with the former being superior in cytotoxicity compared to the latter. The tumor size was almost diminished 1 month post-photodynamic treatment for both systems with regression in the number of tumor cells upon histopathological evaluation, with curcumin liposomes producing better tumor regression than gold nanoparticles with comparable survival rate. Liposomes were confirmed to be superior to gold nanoparticles as a photodynamic treatment modality for cancer. |
| فهرسة مساهمة: | Keywords: Curcumin; cancer; gold nanoparticles; liposomes; photodynamic therapy |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Liposomes) IT942ZTH98 (Curcumin) |
| تواريخ الأحداث: | Date Created: 20180704 Date Completed: 20190123 Latest Revision: 20220409 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/03639045.2018.1496451 |
| PMID: | 29969300 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1520-5762 |
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| DOI: | 10.1080/03639045.2018.1496451 |