دورية أكاديمية
Downgrading and Upgrading Gray-Scale Ultrasound BI-RADS Categories of Benign and Malignant Masses With Optoacoustics: A Pilot Study.
| العنوان: | Downgrading and Upgrading Gray-Scale Ultrasound BI-RADS Categories of Benign and Malignant Masses With Optoacoustics: A Pilot Study. |
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| المؤلفون: | Neuschler EI; 1 Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N St Clair St, Ste 800, Chicago, IL 60611., Lavin PT; 2 Boston Biostatistics Research Foundation, Framingham, MA., Tucker FL; 3 Virginia Biomedical Laboratories, LLC, Wirtz, VA., Barke LD; 4 Radiologic Imaging Associates, Englewood, CO., Bertrand ML; 5 Solis Mammography Greensboro, Greensboro, NC., Böhm-Vélez M; 6 Weinstein Imaging Associates, Pittsburgh, PA., Destounis S; 7 Elizabeth Wende Breast Care, Rochester, NY., Dogan BE; 8 Department of Radiology and Breast Imaging, MD Anderson Cancer Center, Houston, TX.; 9 Present address: Department of Radiology, UT Southwestern Medical Center, Dallas, TX., Grobmyer SR; 10 Cleveland Clinic, Cleveland, OH., Katzen J; 11 Department of Radiology, Weill Cornell Medicine, New York, NY., Kist KA; 12 UT Health San Antonio, San Antonio, TX., Makariou EV; 13 Department of Radiology, MedStar Georgetown University Hospital, Washington, DC., Parris TM; 14 Breastlink Temecula Valley, Murrieta, CA., Young CA; 15 Austin Radiological Association, Austin, TX.; 16 Present address: Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, MO., Butler R; 17 Department of Radiology and Biomedical Imaging, Yale-New Haven Hospital/Smilow Cancer Hospital, New Haven, CT. |
| المصدر: | AJR. American journal of roentgenology [AJR Am J Roentgenol] 2018 Sep; Vol. 211 (3), pp. 689-700. Date of Electronic Publication: 2018 Jul 05. |
| نوع المنشور: | Clinical Trial, Phase III; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Roentgen Ray Society Country of Publication: United States NLM ID: 7708173 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-3141 (Electronic) Linking ISSN: 0361803X NLM ISO Abbreviation: AJR Am J Roentgenol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2004-> : Leesburg, VA : American Roentgen Ray Society Original Publication: Springfield, Ill., Thomas. |
| مواضيع طبية MeSH: | Breast Neoplasms/*diagnostic imaging , Breast Neoplasms/*pathology , Photoacoustic Techniques/*methods , Ultrasonography, Mammary/*methods, Adult ; Aged ; False Negative Reactions ; False Positive Reactions ; Female ; Humans ; Middle Aged ; Neoplasm Grading ; Pilot Projects ; Prospective Studies ; Sensitivity and Specificity |
| مستخلص: | Objective: False-positive findings remain challenging in breast imaging. This study investigates the incremental value of optoacoustic imaging in improving BI-RADS categorization of breast masses at ultrasound. Subjects and Methods: The study device is an optoacoustic breast imaging device with a handheld duplex laser and internal gray-scale ultrasound probe, fusing functional and morphologic information (optoacoustic ultrasound). In this prospective multisite study, breast masses assessed as BI-RADS category 3, 4A, 4B, 4C, or 5 by site radiologists underwent both gray-scale ultrasound and optoacoustic imaging with the study device. Independent reader radiologists assessed internal gray-scale ultrasound and optoacoustic ultrasound features for each mass and assigned a BI-RADS category. The percentage of mass reads for which optoacoustic ultrasound resulted in a downgrade or upgrade of BI-RADS category relative to internal gray-scale ultrasound was determined. Results: Of 94 total masses, 39 were biopsy-proven malignant, 44 were biopsy-proven benign, and 11 BI-RADS category 3 masses were stable at 12-month follow-up. The sensitivity of both optoacoustic ultrasound and internal gray-scale ultrasound was 97.1%. The specificity was 44.3% for optoacoustic ultrasound and 36.4% for internal gray-scale ultrasound. Using optoacoustic ultrasound, 41.7% of benign masses or BI-RADS category 3 masses that were stable at 12-month follow-up were downgraded to BI-RADS category 2 by independent readers; 36.6% of masses assigned BI-RADS category 4A were downgraded to BI-RADS category 3 or 2, and 10.1% assigned BI-RADS category 4B were downgraded to BI-RADS category 3 or 2. Using optoacoustic ultrasound, independent readers upgraded 75.0% of the malignant masses classified as category 4A, 4B, 4C, or 5, and 49.4% of the malignant masses were classified as category 4B, 4C, or 5. Conclusion: Optoacoustic ultrasound resulted in BI-RADS category downgrading of benign masses and upgrading of malignant masses compared with gray-scale ultrasound. |
| فهرسة مساهمة: | Keywords: BI-RADS; breast cancer; breast ultrasound; optoacoustic imaging; photoacoustic imaging |
| تواريخ الأحداث: | Date Created: 20180706 Date Completed: 20190613 Latest Revision: 20190613 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2214/AJR.17.18436 |
| PMID: | 29975115 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1546-3141 |
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| DOI: | 10.2214/AJR.17.18436 |