دورية أكاديمية
Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells.
| العنوان: | Mesenchymal Stromal Cells Stimulate the Proliferation and IL-22 Production of Group 3 Innate Lymphoid Cells. |
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| المؤلفون: | van Hoeven V; Department of Hematology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Cancer Center Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and., Munneke JM; Department of Hematology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Cancer Center Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and., Cornelissen AS; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, 1066 CX Amsterdam, the Netherlands., Omar SZ; Department of Hematology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Cancer Center Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and., Spruit MJ; Department of Hematology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Cancer Center Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and., Kleijer M; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, 1066 CX Amsterdam, the Netherlands., Bernink JH; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and., Blom B; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Cancer Center Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and., Voermans C; Department of Hematopoiesis, Sanquin Research and Landsteiner Laboratory, 1066 CX Amsterdam, the Netherlands., Hazenberg MD; Department of Hematology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands; m.d.hazenberg@amc.uva.nl.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Cancer Center Amsterdam, 1105 AZ Amsterdam, the Netherlands.; Amsterdam Infection and Immunity Institute, 1105 AZ Amsterdam, the Netherlands; and. |
| المصدر: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2018 Aug 15; Vol. 201 (4), pp. 1165-1173. Date of Electronic Publication: 2018 Jul 06. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Bethesda, MD : American Association of Immunologists Original Publication: Baltimore : Williams & Wilkins, c1950- |
| مواضيع طبية MeSH: | Mesenchymal Stem Cell Transplantation*, Graft vs Host Disease/*therapy , Interleukins/*metabolism , Lymphocytes/*immunology , Mesenchymal Stem Cells/*physiology, Cell Proliferation ; Cells, Cultured ; Coculture Techniques ; Homeostasis ; Humans ; Immunity, Innate ; Intercellular Adhesion Molecule-1/metabolism ; Lymphocyte Activation ; Transplantation, Homologous ; Vascular Cell Adhesion Molecule-1/metabolism ; Interleukin-22 |
| مستخلص: | Infusion of mesenchymal stromal cells (MSCs) is a promising and increasingly applied therapy for patients who suffer from a variety of inflammatory diseases, including graft-versus-host disease (GvHD), a common and life-threatening complication after allogeneic hematopoietic stem cell transplantation. The therapeutic effect of MSCs is mainly ascribed to their ability to suppress T cells and to support tissue repair. However, clinical response rates in patients with GvHD are limited to 50%, and the determinants for MSC responsiveness are unknown. We recently reported that high frequencies of activated group 3 innate lymphoid cells (ILC3s) before and after allogeneic hematopoietic stem cell transplantation were associated with a lower risk of GvHD. This may be related to IL-22 production by ILC3s, a cytokine important for intestinal epithelial cell homeostasis. In this study, we investigated whether ILC3s may contribute to the therapeutic effect of MSCs by studying the interaction between MSCs and ILC3s in vitro. ILC3s isolated from human tonsils were cocultured with human bone marrow-derived MSCs for 5 d in the presence of IL-2. Coculture with MSCs enhanced the proliferation and IL-22 production of ILC3s. Reciprocally, ILC3s promoted ICAM-1 and VCAM-1 expression on MSCs. For both directions, the activation was mainly mediated by cell-cell contact and by MSC-derived IL-7 and likely by aryl hydrocarbon receptor ligands. Thus, in addition to inhibiting the proliferation of alloreactive T cells, MSCs also promote the expansion and IL-22 production of ILC3s, which may contribute to healthy homeostasis and wound repair in the treatment of various inflammatory conditions in the intestine, including GvHD. (Copyright © 2018 by The American Association of Immunologists, Inc.) |
| المشرفين على المادة: | 0 (Interleukins) 0 (Vascular Cell Adhesion Molecule-1) 126547-89-5 (Intercellular Adhesion Molecule-1) |
| تواريخ الأحداث: | Date Created: 20180708 Date Completed: 20190709 Latest Revision: 20231213 |
| رمز التحديث: | 20240628 |
| DOI: | 10.4049/jimmunol.1700901 |
| PMID: | 29980610 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-6606 |
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| DOI: | 10.4049/jimmunol.1700901 |