دورية أكاديمية
أعرض في EDS

Rhodiola rosea Improves Lifespan, Locomotion, and Neurodegeneration in a Drosophila melanogaster Model of Huntington's Disease.

التفاصيل البيبلوغرافية
العنوان: Rhodiola rosea Improves Lifespan, Locomotion, and Neurodegeneration in a Drosophila melanogaster Model of Huntington's Disease.
المؤلفون: Arabit JGJ; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Elhaj R; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Schriner SE; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Sevrioukov EA; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA., Jafari M; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, CA, USA.
المصدر: BioMed research international [Biomed Res Int] 2018 Jun 10; Vol. 2018, pp. 6726874. Date of Electronic Publication: 2018 Jun 10 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Drosophila melanogaster* , Rhodiola*, Huntington Disease/*drug therapy , Plant Extracts/*therapeutic use, Animals ; Disease Models, Animal ; Locomotion/drug effects ; Longevity/drug effects ; Neurodegenerative Diseases/drug therapy
مستخلص: Huntington's disease (HD) is a dominant, late-onset disease characterized by choreiform movements, cognitive decline, and personality disturbance. It is caused by a polyglutamine repeat expansion in the Huntington's disease gene encoding for the Huntingtin protein (Htt) which functions as a scaffold for selective macroautophagy. Mutant Htt (mHtt) disrupts vesicle trafficking and prevents autophagosome fusion with lysosomes, thus deregulating autophagy in neuronal cells, leading to cell death. Autophagy has been described as a therapeutic target for HD, owing to the key role Htt plays in the cellular process. Rhodiola rosea , a plant extract used in traditional medicine in Europe and Asia, has been shown to attenuate aging in the fly and other model species. It has also been shown to inhibit the mTOR pathway and induce autophagy in bladder cancer cell lines. We hypothesized that R. rosea , by inducing autophagy, may improve the phenotype of a Huntington's disease model of the fly. Flies expressing HttQ93 which exhibit decreased lifespan, impaired locomotion, and increased neurodegeneration were supplemented with R. rosea extract, and assays testing lifespan, locomotion, and pseudopupil degeneration provided quantitative measures of improvement. Based on our observations, R. rosea may be further evaluated as a potential therapy for Huntington's disease.
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المشرفين على المادة: 0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20180710 Date Completed: 20190114 Latest Revision: 20190114
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6015705
DOI: 10.1155/2018/6726874
PMID: 29984244
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2018/6726874