دورية أكاديمية

Myrianthus arboreus P. Beauv (Cecropiaceae) Extracts Accelerates Sexual Maturation, and Increases Fertility Index and Gestational Rate in Female Wistar Rats.

التفاصيل البيبلوغرافية
العنوان: Myrianthus arboreus P. Beauv (Cecropiaceae) Extracts Accelerates Sexual Maturation, and Increases Fertility Index and Gestational Rate in Female Wistar Rats.
المؤلفون: Awounfack CF; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. c.awounfack@yahoo.fr., Mvondo MA; Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon. Mvondo.mariealfrede@yahoo.com., Zingue S; Laboratory of Physiology, Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon. stephanezingue@gmail.com., Ateba SB; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. s.benjaminateba@gmail.com., Djiogue S; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. sefirindjiogue@gmail.com., Megnekou R; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. megnekor@yahoo.fr., Tantoh Ndinteh D; Department of applied Chemistry, Faculty of Science, University of Johannesburg, P.O. Box 17011, Gauteng, South Africa. dndinteh@uj.ac.za., Njamen D; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. dnjamen@gmail.com.
المصدر: Medicines (Basel, Switzerland) [Medicines (Basel)] 2018 Jul 07; Vol. 5 (3). Date of Electronic Publication: 2018 Jul 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101671069 Publication Model: Electronic Cited Medium: Print ISSN: 2305-6320 (Print) Linking ISSN: 23056320 NLM ISO Abbreviation: Medicines (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2014]-
مستخلص: Background: Despite the wide use of leaves of Myrianthus arboreus (Cecropiaceae) in several African countries including Cameroon as food and against amenorrhea and female infertility, it has never been tested for this purpose. Methods: Using immature female Wistar rats, the impact of M. arboreus on the sexual maturation parameters (vaginal opening, ovarian relative weight and follicle maturation, gonadotropins and ovarian hormones serum levels) and fertility index has been evaluated through a 30-day oral administration of aqueous and methanol extracts of leaves at the doses of 20, 110 and 200 g/kg/day. Results: Aqueous extract increased the ovarian relative weight ( p < 0.001), progesterone ( p < 0.001) and gonadotropins ( p < 0.001) serum levels, and induced the maturation of ovarian follicles. The methanol extract additionally induced an early vaginal opening ( p < 0.001), uterine growth ( p < 0.01) and increased estradiol ( p < 0.001) serum levels. The fertility index generally increased following treatments, while the gestation rate remained almost unaffected except at the highest tested dose of M. arboreus extracts where lowest values were observed. Conclusion: Globally, M. arboreus induced an early puberty onset and an increased fertility rate validating at least in part its traditional use for female infertility.
References: J Food Drug Anal. 2014 Sep;22(3):296-302. (PMID: 28911418)
PLoS Med. 2012;9(12):e1001356. (PMID: 23271957)
J Ovarian Res. 2014 May 08;7:51. (PMID: 24829615)
J Transl Med. 2006 Dec 27;4:54. (PMID: 17192178)
Bull World Health Organ. 2010 Dec 1;88(12):881-2. (PMID: 21124709)
J Psychosom Obstet Gynaecol. 2010 Jun;31(2):101-10. (PMID: 20443659)
J Ethnopharmacol. 1999 Nov 30;67(3):253-8. (PMID: 10617059)
Int J Gynaecol Obstet. 2009 Aug;106(2):168-71. (PMID: 19535067)
Toxicol Pathol. 2014;42(2):403-13. (PMID: 23599412)
Afr J Tradit Complement Altern Med. 2007 Jun 10;4(4):495-500. (PMID: 20161918)
Mol Endocrinol. 2003 Oct;17(10):2070-83. (PMID: 12893882)
J Reprod Med. 2007 Nov;52(11):1059-62. (PMID: 18161408)
Springerplus. 2015 Oct 01;4:567. (PMID: 26543702)
Reprod Toxicol. 2014 Apr;44:85-92. (PMID: 24365114)
Hum Reprod. 2007 Jun;22(6):1506-12. (PMID: 17376819)
Reprod Health Matters. 2000 May;8(15):33-44. (PMID: 11424266)
J Ethnopharmacol. 2018 Jan 30;211:117-125. (PMID: 28951243)
Antioxidants (Basel). 2015 Jun 09;4(2):410-26. (PMID: 26783713)
J Ethnopharmacol. 2013 Oct 28;150(1):298-307. (PMID: 24012967)
Perspect Public Health. 2013 May;133(3):174-9. (PMID: 23327901)
J Reprod Fertil. 1981 Mar;61(2):373-80. (PMID: 7205783)
Br Med Bull. 2000;56(3):577-87. (PMID: 11255546)
J Clin Endocrinol Metab. 1998 Dec;83(12):4177-88. (PMID: 9851748)
Birth Defects Res B Dev Reprod Toxicol. 2011 Aug;92(4):261-5. (PMID: 21594977)
Annu Rev Pharmacol Toxicol. 2003;43:175-97. (PMID: 12195028)
J Ethnopharmacol. 2015 Aug 2;171:94-8. (PMID: 26002765)
Reprod Biol Endocrinol. 2015 Apr 26;13:37. (PMID: 25928197)
Hum Reprod Update. 2015 Jul-Aug;21(4):411-26. (PMID: 25801630)
Sociol Health Illn. 2010 Jan;32(1):140-62. (PMID: 20003036)
J Ethnopharmacol. 2015 Feb 23;161:156-62. (PMID: 25527316)
Fertil Steril. 2012 Nov;98(5):1283-90. (PMID: 22854013)
J Basic Clin Physiol Pharmacol. 2015 May;26(3):287-94. (PMID: 25153589)
J Ethnopharmacol. 2009 Jan 21;121(2):229-33. (PMID: 19015020)
Afr Health Sci. 2009 Mar;9(1):49-53. (PMID: 20842243)
J Ethnopharmacol. 2016 Dec 24;194:169-178. (PMID: 27592311)
Hum Reprod. 2005 May;20(5):1144-7. (PMID: 15802321)
Methods Mol Med. 2006;121:9-34. (PMID: 16251731)
Best Pract Res Clin Endocrinol Metab. 2011 Dec;25(6):861-73. (PMID: 22115162)
Toxicol Sci. 2001 Aug;62(2):330-8. (PMID: 11452146)
J Pharm Pharmacol. 2015 Jul;67(7):990-6. (PMID: 25683903)
Acta Histochem. 2012 May;114(3):270-5. (PMID: 21703666)
BMC Complement Altern Med. 2012 Apr 06;12:36. (PMID: 22482701)
فهرسة مساهمة: Keywords: Myrianthus arboreus; Wistar rats; female infertility; folliculogenesis; gestational rate; gonadotrophins
تواريخ الأحداث: Date Created: 20180711 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6163494
DOI: 10.3390/medicines5030073
PMID: 29986496
قاعدة البيانات: MEDLINE
الوصف
تدمد:2305-6320
DOI:10.3390/medicines5030073