دورية أكاديمية
أعرض في EDS

Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses.

التفاصيل البيبلوغرافية
العنوان: Avian influenza A H7N9 virus infects human astrocytes and neuronal cells and induces inflammatory immune responses.
المؤلفون: Ng YP; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Yip TF; HKU-Pasteur Research Pole and Centre of Influenza Research, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Peiris JSM; HKU-Pasteur Research Pole and Centre of Influenza Research, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China., Ip NY; Division of Life Science, The Hong Kong University of Science and Technology, Hong Kong, China., Lee SMY; HKU-Pasteur Research Pole and Centre of Influenza Research, School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. suki@hku.hk.
المصدر: Journal of neurovirology [J Neurovirol] 2018 Dec; Vol. 24 (6), pp. 752-760. Date of Electronic Publication: 2018 Jul 09.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 9508123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-2443 (Electronic) Linking ISSN: 13550284 NLM ISO Abbreviation: J Neurovirol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2011- : New York : Springer
Original Publication: Houndmills, Basingstoke, Hampshire ; New York, NY : Stockton Press, c1995-
مواضيع طبية MeSH: Astrocytes/*virology , Influenza A Virus, H7N9 Subtype/*physiology , Influenza, Human/*virology , Neurons/*virology, Humans ; Inflammation/immunology ; Inflammation/virology ; Influenza, Human/immunology ; Virus Replication
مستخلص: Seasonal, pandemic, and avian influenza virus infections may be associated with central nervous system pathology, albeit with varying frequency and different mechanisms. Here, we demonstrate that differentiated human astrocytic (T98G) and neuronal (SH-SY5Y) cells can be infected by avian H7N9 and pandemic H1N1 viruses. However, infectious progeny viruses can only be detected in H7N9 virus infected human neuronal cells. Neither of these viral strains can generate infectious progeny virus in human astrocytes despite replication of viral genome was observed. Furthermore, H7N9 virus triggered high pro-inflammatory cytokine expression, while pandemic H1N1 virus induced only low cytokine expression in either brain cell type. The experimental finding here is the first data to demonstrate that avian H7N9 virus can infect, transcribe, and replicate its viral genome; induce cytokine upregulation; and cause cytopathic effects in human brain cells, which may potentially lead to profound central nervous system injury. Observation for neurological problems due to H7N9 virus infection deserves further attention when managing these patients.
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فهرسة مساهمة: Keywords: Cytokines; Encephalitis; Encephalopathy; Neurodegenerative diseases; Neuroinflammation; Neurological complications
تواريخ الأحداث: Date Created: 20180711 Date Completed: 20191112 Latest Revision: 20200327
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7094989
DOI: 10.1007/s13365-018-0659-8
PMID: 29987581
قاعدة البيانات: MEDLINE
الوصف
تدمد:1538-2443
DOI:10.1007/s13365-018-0659-8