دورية أكاديمية
Human and Bovine Colostrum for Prevention of Necrotizing Enterocolitis: A Meta-analysis.
| العنوان: | Human and Bovine Colostrum for Prevention of Necrotizing Enterocolitis: A Meta-analysis. |
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| المؤلفون: | Sadeghirad B; Department of Health Research Methods, Evidence, and Impact and.; The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Canada.; HIV/STI Surveillance Research Center, World Health Organization Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran., Morgan RL; Department of Health Research Methods, Evidence, and Impact and., Zeraatkar D; Department of Health Research Methods, Evidence, and Impact and., Zea AM; School of Nutrition and Dietetics, University of Antioquia, Medellin, Colombia; and., Couban R; The Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, Canada., Johnston BC; Department of Health Research Methods, Evidence, and Impact and.; Department of Community Health and Epidemiology, Medicine, Dalhousie University, Halifax, Canada., Florez ID; Department of Health Research Methods, Evidence, and Impact and ivan.florez@udea.edu.co.; Department of Pediatrics and. |
| المصدر: | Pediatrics [Pediatrics] 2018 Aug; Vol. 142 (2). Date of Electronic Publication: 2018 Jul 10. |
| نوع المنشور: | Journal Article; Meta-Analysis; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Academy of Pediatrics Country of Publication: United States NLM ID: 0376422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-4275 (Electronic) Linking ISSN: 00314005 NLM ISO Abbreviation: Pediatrics Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Elk Grove Village Il : American Academy of Pediatrics Original Publication: Springfield, Ill., Thomas. |
| مواضيع طبية MeSH: | Colostrum/*physiology , Enterocolitis, Necrotizing/*prevention & control, Administration, Oral ; Animals ; Cattle ; Enteral Nutrition/methods ; Enterocolitis, Necrotizing/diagnosis ; Enterocolitis, Necrotizing/epidemiology ; Humans ; Length of Stay/trends ; Mortality/trends ; Randomized Controlled Trials as Topic/methods |
| مستخلص: | Context: Human and bovine colostrum (HBC) administration has been linked to beneficial effects on morbidity and mortality associated with necrotizing enterocolitis (NEC). Objectives: To determine the effectiveness and safety of HBC for reducing NEC, mortality, sepsis, time to full-feed and feeding intolerance in preterm infants. Data Sources: We conducted searches through Medline, Embase, Cumulative Index of Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, and gray literature. Study Selection: Randomized controlled trials comparing human or bovine colostrum to placebo. Data Extraction: Two reviewers independently did screening, review, and extraction. Results: Eight studies (385 infants) proved eligible. In comparison with placebo, HBC revealed no effect on the incidence of severe NEC (relative risk [RR]: 0.99; 95% confidence interval [CI] 0.48 to 2.02, I 2 = 2.2%; moderate certainty of evidence), all-cause mortality (RR: 0.88; 95% CI 0.39 to 1.82, I 2 = 0%; moderate certainty), culture-proven sepsis (RR: 0.78; 95% CI 0.53 to 1.14, I 2 = 0%; moderate certainty), and feed intolerance (RR: 0.97; 95% CI 0.37 to 2.56, I 2 = 55%; low certainty). HBC revealed a significant effect on reducing the mean days to reach full enteral feed (mean difference: -3.55; 95% CI 0.33 to 6.77, I 2 = 41.1%; moderate certainty). The indirect comparison of bovine versus human colostrum revealed no difference in any outcome. Limitations: The number of patients was modest, whereas the number of NEC-related events was low. Conclusions: Bovine or human colostrum has no effect on severe NEC, mortality, culture-proven sepsis, feed intolerance, or length of stay. Additional research focused on the impact on enteral feeding may be needed to confirm the findings on this outcome. Competing Interests: POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose. (Copyright © 2018 by the American Academy of Pediatrics.) |
| تواريخ الأحداث: | Date Created: 20180712 Date Completed: 20190501 Latest Revision: 20190501 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1542/peds.2018-0767 |
| PMID: | 29991526 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1098-4275 |
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| DOI: | 10.1542/peds.2018-0767 |