دورية أكاديمية
أعرض في EDS

Effect of Model Thrombus Volume and Elastic Modulus on Magnetomotive Ultrasound Signal Under Pulsatile Flow.

التفاصيل البيبلوغرافية
العنوان: Effect of Model Thrombus Volume and Elastic Modulus on Magnetomotive Ultrasound Signal Under Pulsatile Flow.
المؤلفون: Levy BE, Hossain MM, Sierchio JM, Thapa D, Gallippi CM, Oldenburg AL
المصدر: IEEE transactions on ultrasonics, ferroelectrics, and frequency control [IEEE Trans Ultrason Ferroelectr Freq Control] 2018 Aug; Vol. 65 (8), pp. 1380-1388. Date of Electronic Publication: 2018 May 28.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Institute of Electrical and Electronics Engineers Country of Publication: United States NLM ID: 9882735 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-8955 (Electronic) Linking ISSN: 08853010 NLM ISO Abbreviation: IEEE Trans Ultrason Ferroelectr Freq Control Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Institute of Electrical and Electronics Engineers, c1985-
مواضيع طبية MeSH: Ultrasonography*/instrumentation , Ultrasonography*/methods, Blood Vessels/*diagnostic imaging , Elastic Modulus/*physiology , Pulsatile Flow/*physiology , Thrombosis/*diagnostic imaging, Angiography ; Humans ; Magnetite Nanoparticles/chemistry ; Models, Cardiovascular ; Phantoms, Imaging
مستخلص: Direct ultrasonic imaging of arterial and venous thrombi could aid in diagnosis and treatment planning by providing rapid and cost-effective measurements of thrombus volume and elastic modulus. Toward this end, it was demonstrated that open-air magnetomotive ultrasound (MMUS) provides specific contrast to superparamagnetic iron oxide-labeled model thrombi embedded in gelatin-based blood vessel-mimicking flow phantoms. MMUS was performed on model thrombi in the presence of pulsatile flow that mimics cardiac-induced motion found in real vasculature. The MMUS signal and contrast-to-noise ratio (CNR) were measured across a range of physiologically relevant thrombus volumes and elastic moduli. Model thrombus volumes as small as 0.5 ml were shown to be detectable (CNR > 1) over the entire range of elastic moduli tested (3.5-40 kPa). It was also found that MMUS signal and CNR are increased with increasing thrombus volume ( ) and decreasing elastic modulus ( ), while variations in pulsatile flow rate had little effect. These findings demonstrate that MMUS has promise as a direct in vivo thrombosis imaging modality for quantifying thrombus volume and stiffness.
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معلومات مُعتمدة: R21 HL109832 United States HL NHLBI NIH HHS; R21 HL119928 United States HL NHLBI NIH HHS
المشرفين على المادة: 0 (Magnetite Nanoparticles)
تواريخ الأحداث: Date Created: 20180712 Date Completed: 20190830 Latest Revision: 20230928
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC6190700
DOI: 10.1109/TUFFC.2018.2841774
PMID: 29993541
قاعدة البيانات: MEDLINE
الوصف
تدمد:1525-8955
DOI:10.1109/TUFFC.2018.2841774