دورية أكاديمية
Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia.
| العنوان: | Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia. |
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| المؤلفون: | Gong S; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre., Sovio U; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience., Aye IL; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience., Gaccioli F; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience., Dopierala J; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience., Johnson MD; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience., Wood AM; Department of Public Health and Primary Care., Cook E; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre., Jenkins BJ; NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge, United Kingdom., Koulman A; NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge, United Kingdom., Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA., Constância M; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience.; University of Cambridge Metabolic Research Laboratories and MRC Metabolic Diseases Unit, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, United Kingdom., Charnock-Jones DS; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience., Smith GC; Department of Obstetrics and Gynaecology, NIHR Cambridge Comprehensive Biomedical Research Centre.; Centre for Trophoblast Research (CTR), Department of Physiology, Development and Neuroscience. |
| المصدر: | JCI insight [JCI Insight] 2018 Jul 12; Vol. 3 (13). Date of Electronic Publication: 2018 Jul 12. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Ann Arbor, Michigan : American Society for Clinical Investigation, [2016]- |
| مواضيع طبية MeSH: | Fetal Growth Retardation/*metabolism , Placenta/*metabolism , Polyamines/*metabolism , Pre-Eclampsia/*metabolism, Cell Survival ; Female ; Fetal Development ; Fetal Growth Retardation/genetics ; Gene Expression Regulation ; Genes, X-Linked/genetics ; Gestational Age ; Humans ; Male ; Pre-Eclampsia/genetics ; Pregnancy ; Pregnancy Complications/blood ; Prospective Studies ; Risk Assessment ; Sequence Analysis, RNA ; Sex Factors ; Spermine/metabolism ; Spermine Synthase/blood ; Transcriptome ; Trophoblasts ; Ultrasonography, Prenatal ; United Kingdom |
| مستخلص: | Preeclampsia and fetal growth restriction (FGR) are major causes of the more than 5 million perinatal and infant deaths occurring globally each year, and both are associated with placental dysfunction. The risk of perinatal and infant death is greater in males, but the mechanisms are unclear. We studied data and biological samples from the Pregnancy Outcome Prediction (POP) study, a prospective cohort study that followed 4,212 women having first pregnancies from their dating ultrasound scan through delivery. We tested the hypothesis that fetal sex would be associated with altered placental function using multiomic and targeted analyses. We found that spermine synthase (SMS) escapes X-chromosome inactivation (XCI) in the placenta and is expressed at lower levels in male primary trophoblast cells, and male cells were more sensitive to polyamine depletion. The spermine metabolite N1,N12-diacetylspermine (DiAcSpm) was higher in the female placenta and in the serum of women pregnant with a female fetus. Higher maternal serum levels of DiAcSpm increased the risk of preeclampsia but decreased the risk of FGR. To our knowledge, DiAcSpm is the first maternal biomarker to demonstrate opposite associations with preeclampsia and FGR, and this is the first evidence to implicate polyamine metabolism in sex-related differences in placentally related complications of human pregnancy. |
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| معلومات مُعتمدة: | MC_UU_12012/4 United Kingdom MRC_ Medical Research Council; MR/L003120/1 United Kingdom MRC_ Medical Research Council; RG/13/13/30194 United Kingdom BHF_ British Heart Foundation; MR/K021133/1 United Kingdom MRC_ Medical Research Council; G1100221 United Kingdom MRC_ Medical Research Council; MRC_MC_UU_12012/4 United Kingdom MRC_ Medical Research Council; R01 CA204345 United States CA NCI NIH HHS; MC_UU_12012/5 United Kingdom MRC_ Medical Research Council; MC_UU_00014/4 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Expression profiling; Obstetrics/gynecology; Polyamines; Reproductive Biology |
| المشرفين على المادة: | 0 (Polyamines) 2FZ7Y3VOQX (Spermine) EC 2.5.1.22 (Spermine Synthase) |
| تواريخ الأحداث: | Date Created: 20180713 Date Completed: 20191104 Latest Revision: 20230201 |
| رمز التحديث: | 20230201 |
| مُعرف محوري في PubMed: | PMC6124516 |
| DOI: | 10.1172/jci.insight.120723 |
| PMID: | 29997303 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2379-3708 |
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| DOI: | 10.1172/jci.insight.120723 |