دورية أكاديمية
Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review.
| العنوان: | Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. |
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| المؤلفون: | Nogueira AO; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275.; Higher Institute of Biomedical Sciences, Av. Dr. Silas Munguba, 1700, Itaperi, Fortaleza, Brazil, 60741-000., Oliveira YIS; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275., Adjafre BL; Higher Institute of Biomedical Sciences, Av. Dr. Silas Munguba, 1700, Itaperi, Fortaleza, Brazil, 60741-000., de Moraes MEA; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275., Aragão GF; Drug Discovery and Developmente Center, Federal University of Ceara, St. Coronel Nunes de Melo, 1000, Rodolfo Teófilo, Fortaleza, Brazil, 60430-275.; Medicine Course, State University of Ceara, Av. Dr. Silas Munguba, 1700, Itaperi, Fortaleza, Brazil, 60741-000. |
| المصدر: | Fundamental & clinical pharmacology [Fundam Clin Pharmacol] 2019 Feb; Vol. 33 (1), pp. 4-12. Date of Electronic Publication: 2018 Aug 05. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Science Country of Publication: England NLM ID: 8710411 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1472-8206 (Electronic) Linking ISSN: 07673981 NLM ISO Abbreviation: Fundam Clin Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: Oxford : Blackwell Science Original Publication: Paris ; New York : Elsevier, c1987- |
| مواضيع طبية MeSH: | Burseraceae/*chemistry , Oleanolic Acid/*analogs & derivatives, Animals ; Humans ; Oleanolic Acid/chemistry ; Oleanolic Acid/isolation & purification ; Oleanolic Acid/pharmacology ; Phytotherapy/methods ; Resins, Plant/chemistry ; Stereoisomerism |
| مستخلص: | Protium heptaphyllum Aubl. belongs to the Burseraceae family. It is commonly called 'almecegueira' and is known to produce an amorphous resin which has constituents such as α- and β-amyrin, taraxastan-3-oxo-20-ol and sitostenonein. The α- and β-amyrin from P. heptaphyllum have pharmacological activities in several systems, such as central and peripheral nervous system, gastrointestinal tract and immunological system. In this study, our objective was to review pharmacological activities and to gather more information on the mixture of α- and β-amyrin obtained from P. heptaphyllum to guide future preclinical and clinical studies using this compound. This review consisted of searches performed using scientific databases such as PubMed, SciELO, LILACS, SciFinder and Science Direct. Some uses of α- and β-amyrin have been partially confirmed by previous studies demonstrating analgesic, anti-inflammatory, anticonvulsant, antidepressive, gastroprotective, hepatoprotective, antipancreatitic, anticholytic, antihyperglycemic and hypolipidemic effects. It is noteworthy that there are no α- and β-amirin toxicity tests described in the literature as recommended in the international guidelines, and such tests are one of the research stages to proceed in clinical and preclinical trials if this compound was to be used. (© 2018 Société Française de Pharmacologie et de Thérapeutique.) |
| فهرسة مساهمة: | Keywords: Protium heptaphyllum; pharmacological properties; α and β amyrin |
| المشرفين على المادة: | 0 (Resins, Plant) 6SMK8R7TGJ (Oleanolic Acid) KM8353IPSO (beta-amyrin) |
| تواريخ الأحداث: | Date Created: 20180714 Date Completed: 20190412 Latest Revision: 20191210 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/fcp.12402 |
| PMID: | 30003594 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1472-8206 |
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| DOI: | 10.1111/fcp.12402 |